Results 221 to 230 of about 14,444,288 (391)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Regulation to function: A computational approach to specialized metabolism. [PDF]

PLoS Biol
Nodwell JR.
europepmc   +1 more source

The emerging functions of the p53-miRNA network in stem cell biology [PDF]

, 2012
Chao‐Po Lin, Yong Jin Choi, Geoffrey G. Hicks, Lin He   +3 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Gene Ontology: tool for the unification of biology

Nature Genetics, 2000
Michael Ashburner, C. Ball, J. Blake, D. Botstein, Heather L. Butler, J. Cherry, A. P. Davis, K. Dolinski, S. Dwight, J. Eppig, M. Harris, D. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. Matese, J. Richardson, Martin, Ringwald, G. Rubin, G. Sherlock   +20 more
semanticscholar   +1 more source

Condensate dynamics at the synapse: Phase separation tunes presynaptic function. [PDF]

PLoS Biol
Lützkendorf J, Sigrist SJ.
europepmc   +1 more source

Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging [PDF]

, 2012
Nicole S. Hou, Stefan Taubert
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Subjective assessment of sensory function and oral function decline in older adults. [PDF]

PLoS One
Ichikawa T, Koda T, Kitamura M, Kishimoto T, Matsuda T, Goto T, Domichi M, Suganuma A, Fujiwara S, Shirayama Y, Kotani K, Sakane N.   +11 more
europepmc   +1 more source

Antisense oligodeoxynucleotide inhibition as a potent diagnostic tool for gene function in plant biology [PDF]

, 2008
Christer Jansson, Chuanxin Sun, Haile Ghebramedhin, Anna‐Stina Höglund, Christer Jansson   +4 more
openalex