Results 221 to 230 of about 3,539,296 (346)

Distinguishing between "Function" and "Effect" in Genome Biology [PDF]

, 2014
W. Ford Doolittle, T. D. P. Brunet, Stefan Linquist, T. Ryan Gregory   +3 more
openalex   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Disruption of photoreceptor cilia is a critical event in the pathogenesis of retinal degeneration—Insights from N-methyl-N-nitrosourea-induced mouse model

Medicine Plus
Guizhi Guo, Runa Wang, Yufei Zhang, Zhiyi Wang, Lin Li, Miaoyuan Liu, Jun Zhou, Jie Ran   +7 more
doaj   +1 more source

SuperEdgeGO: Edge-supervised graph representation learning for enhanced protein function prediction. [PDF]

PLoS Comput Biol
Zhang S, Li Y, Ma W, Cai Q, Qin J, Bi X, Jiang H, Huang X, Wei Z.   +8 more
europepmc   +1 more source

Implementation of a Project-Based Molecular Biology Laboratory Emphasizing Protein Structure–Function Relationships in a Large Introductory Biology Laboratory Course

, 2011
Daniel J. Treacy, Saumya M. Sankaran, Susannah Gordon-Messer, Danielle L. Saly, Rebecca Miller, R. Stefan Isaac, Melissa S. Kosinski‐Collins   +6 more
openalex   +1 more source

Comparative genomics of pectinacetylesterases: Insight on function and biology [PDF]

, 2015
Amancio de Souza, Markus Pauly
openalex   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Biological Sequence Representation Methods and Recent Advances: A Review. [PDF]

Biology (Basel)
Zhang H, Shi Y, Wang Y, Yang X, Li K, Im SK, Han Y.   +6 more
europepmc   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Astrocytes serve as integrative hubs regulating sleep and arousal. [PDF]

PLoS Biol
Ingiosi AM.
europepmc   +1 more source