Results 21 to 30 of about 3,596,843 (342)

Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies

open access: yesScientific Reports, 2018
Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity,
B. Madhu Krishna   +4 more
doaj   +1 more source

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

open access: yesBiomolecules, 2021
Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi   +5 more
doaj   +1 more source

The Effect of Milk Replacer Composition on the Intestinal Microbiota of Pre-ruminant Dairy Calves

open access: yesFrontiers in Veterinary Science, 2019
The impact of dietary composition and prebiotics, in promoting the growth of beneficial groups of gut bacteria, is increasingly apparent. Using Illumina MiSeq sequencing of bacterial 16S rRNA genes, this study has aimed to characterize and compare the ...
James Badman   +7 more
doaj   +1 more source

The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models [PDF]

open access: yes, 2012
LetterThis is the final version of the article. Available from SAGE Publications via the DOI in this record.Time-dependent light input is an important feature of computational models of the circadian clock.
Adams, RR   +8 more
core   +1 more source

Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

open access: yesExperimental and Molecular Medicine, 2018
Colorectal cancer: Finding new small molecule drug candidates Mutations in KRAS, a gene regulating cell proliferation, occur in 40–50% of colorectal cancer (CRC) patients.
Wookjin Shin   +8 more
doaj   +1 more source

Utilization of Snakehead Fish Meat for Increasing Kidney Function in Rat Experiencing Physiological Stress

open access: yesBiosaintifika: Journal of Biology & Biology Education, 2018
Physiological stress for a long time can lead to impaired kidney organ function. Snakehead fish meat are known to contain important nutrients such as albumin, glutamine, glycine, cysteine, and various minerals that can improve kidney function. This study
Sunarno Sunarno   +2 more
doaj   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

open access: yesCells, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Harriet R. Ferguson   +2 more
doaj   +1 more source

Nuclear protein phosphatases with Kelch-repeat domains modulate the response to brassinosteroids in Arabidopsis [PDF]

open access: yes, 2004
Perception of the plant steroid hormone brassinolide (BL) by the membrane-associated receptor kinase BRI1 triggers the dephosphorylation and accumulation in the nucleus of the transcriptional modulators BES1 and BZR1.
Caño Delgado, Ana   +5 more
core   +2 more sources

MicroRNA function in myeloid biology

open access: yesBlood, 2011
Abstract The past 5 years have seen an explosion of knowledge about miRNAs and their roles in hematopoiesis, cancer, and other diseases. In myeloid development, there is a growing appreciation for both the importance of particular miRNAs and the unique features of myelopoiesis that are being uncovered by experimental manipulation of ...
OConnell, Ryan M.   +2 more
openaire   +4 more sources

Hybridization is a recurrent evolutionary stimulus in wild yeast speciation

open access: yesNature Communications, 2019
Hybridization can contribute to diversity from the genomic to the species level. Here, Eberlein, Hénault et al. investigate genomic, transcriptomic and phenotypic variation among wild lineages of the yeast Saccharomyces paradoxus and suggest that an ...
Chris Eberlein   +7 more
doaj   +1 more source

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