Results 21 to 30 of about 14,894,566 (393)
The regulation and function of CD20: an “enigma” of B-cell biology and targeted therapy
Haematologica, 2020 The introduction of anti-CD20 monoclonal antibodies such as rituximab, ofatumumab, or obinutuzumab improved the therapy of B-cell malignancies even though the precise physiological role and regulation of CD20 remains unclear. Furthermore, CD20 expression
G. Pavlasová, M. Mraz
semanticscholar +1 more source
Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4‐2 using proteome arrays
Molecular Systems Biology, 2009 Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2–4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain.
Avinash Persaud +8 more
doaj +1 more source
Growth Response of Bruguiera sp. Propagules to Various Plant Growth Regulators [PDF]
BIO Web of ConferencesMangrove forest degradation is a key factor contributing to the decline of mangrove vegetation in Indonesia. To restore their ecological function, artificial regeneration through mangrove rehabilitation is necessary.
Prihastanti Erma +3 more
doaj +1 more source
Lysosomal Biology and Function: Modern View of Cellular Debris Bin
Cells, 2020 Lysosomes are the main proteolytic compartments of mammalian cells comprising of a battery of hydrolases. Lysosomes dispose and recycle extracellular or intracellular macromolecules by fusing with endosomes or autophagosomes through specific waste ...
P. Trivedi +2 more
semanticscholar +1 more source
AlphaFold2 and its applications in the fields of biology and medicine
Signal Transduction and Targeted Therapy, 2023 AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind that can predict three-dimensional (3D) structures of proteins from amino acid sequences with atomic-level accuracy.
Zhenyu Yang +3 more
semanticscholar +1 more source
Arteriosclerosis, Thrombosis, and Vascular Biology, 2011 Recent evidence indicates that stem/progenitor cells are present in the adventitia and participate in vascular repair and the formation of neointimal lesions in severely damaged vessels. Data have also demonstrated that these resident stem/progenitor cells could differentiate into endothelial or smooth muscle cells in response to different stimuli ...
Hu, Yanhua, Xu, Qingbo
openaire +3 more sources
Aligning Multiple Sequences with Genetic Algorithm [PDF]
, 2009 The alignment of biological sequences is a crucial tool in molecular biology and genome analysis. It helps to build a phylogenetic tree of related DNA sequences and also to predict the function and structure of unknown protein sequences by aligning ...
Adebiyi, E. F. +2 more
core +1 more source
A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]
, 2016 Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei +6 more
core +3 more sources
(ADP-ribosyl)hydrolases: structure, function, and biology
Genes & Development, 2020 In this review, Rack et al. provide an overview of the different families of (ADP- ribosyl)hydrolases and discuss their molecular functions, physiological roles, and influence on human health and disease.
J. Rack, L. Palazzo, I. Ahel
semanticscholar +1 more source
Scientific Reports, 2018 Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity,
B. Madhu Krishna +4 more
doaj +1 more source