The structural basis of translational control by eIF2 phosphorylation
Nature Communications, 2019 During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B.
Tomas Adomavicius +6 more
doaj +1 more source
Ipomoeassin-F disrupts multiple aspects of secretory protein biogenesis
Scientific Reports, 2021 The Sec61 complex translocates nascent polypeptides into and across the membrane of the endoplasmic reticulum (ER), providing access to the secretory pathway. In this study, we show that Ipomoeassin-F (Ipom-F), a selective inhibitor of protein entry into
Peristera Roboti +4 more
doaj +1 more source
Herbal Extract Mixture Modulates Intestinal Antioxidative Capacity and Microbiota in Weaning Piglets
Frontiers in Microbiology, 2021 Recently, herbal extracts have been applied in multiple aspects, such as medicine and animal feed. Different compositions of herbal extract mixture (HEM) have various components and diverse functions.
Meiwei Wang +7 more
doaj +1 more source
'Causa efficiens' versus 'Causa finalis': functional explanations in biology [PDF]
, 2011 Biology differs from most sciences in its particular way of dealing with the term ‘function’. On the one hand, questions like ‘What is the function of a trait x?’ seem to be perfectly legitimate, realizing that (most) biologists acknowledge that ...
Kosolosky, Laszlo
core +1 more source
Insights into the functional biology of schistosomes [PDF]
Parasites & Vectors, 2011 The need to discover new treatments for human schistosomiasis has been an important driver for molecular research on schistosomes, a major breakthrough being the publication of the Schistosoma mansoni and Schistosoma japonicum genomes in 2009. This 'Primer' considers recent advances in the understanding of schistosome biology by providing a snapshot of
openaire +4 more sources
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Building Block and Building Rule: Dual Descriptor Method for Biological Sequence Analysis [PDF]
, 2008 The emergence of “Systems Biology” in recent years highlights the systematic viewpoint of bio-system modeling. Building on such a background, Dual Descriptor Method, a generic methodology for biological sequence analysis is proposed. From a
Bin-Guang Ma
core +1 more source
A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT [PDF]
, 2016 Targeted cancer therapy aims to disrupt aberrant cellular signalling pathways. Biomarkers are surrogates of pathway state, but there is limited success in translating candidate biomarkers to clinical practice due to the intrinsic complexity of pathway ...
Boiko, Andrei +6 more
core +3 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Techniques for RNA in vivo imaging in plants [PDF]
, 2014 Since the discovery of small RNAs and RNA silencing, RNA biology has taken a centre stage in cell and developmental biology. Small RNAs, but also mRNAs and other types of cellular and viral RNAs are processed at specific subcellular localizations.
Tilsner, Jens
core +1 more source