Results 61 to 70 of about 1,918,353 (309)

A Molecular Biology Database Digest [PDF]

, 2000
Computational Biology or Bioinformatics has been defined as the application of mathematical and Computer Science methods to solving problems in Molecular Biology that require large scale data, computation, and analysis [18].
Kröger, Peer, Peer Kröger, Bry, François, François Bry   +3 more
core   +1 more source

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Nature Communications, 2018
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells ...
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord   +22 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Predicting protein function by machine learning on amino acid sequences – a critical evaluation [PDF]

, 2007
Copyright @ 2007 Al-Shahib et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use ...
Gilbert, DR, Al-Shahib, A, Breitling, Rainer, Gilbert, D, Breitling, R., Ali Al-Shahib, Breitling, Rainer,, Al-Shahib, Ali, Rainer Breitling, Gilbert, David R., Breitling, R, Breitling Rainer, Shahib, Ali Al-,, Gilbert, D.R., Al-Shahib Ali, Gilbert, David R.,, David R Gilbert, Gilbert David R, Al-Shahib, A.   +18 more
core   +1 more source

Molecular biology II: protein function [PDF]

Surgery (Oxford), 2009
DNA may be viewed as the blueprint for the body, with mRNA/protein the component parts made from this blueprint. However, it is only when proteins are allowed to interact with each other and their surroundings that true biological complexity is achieved.
openaire   +6 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In what sense does 'nothing make sense except in the light of evolution'? [PDF]

, 2008
Dobzhansky argued that biology only makes sense if life on earth has a shared history. But his dictum is often reinterpreted to mean that biology only makes sense in the light of adaptation.
Paul Edmund Griffiths, Griffiths, Paul Edmund   +1 more
core   +1 more source

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

EMBO Reports
Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are largely unknown.
Ting Song, Xueqing Han, Hanxiao Yin, Junkui Zhao, Mingming Ma, Xiaonuan Wen, Chunli Liu, Yiyang Yue, Huijie Zhao, Jun Zhou, Yang Yang, Jie Ran, Min Liu   +12 more
doaj   +1 more source

IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis

Scientific Reports, 2017
Myeloid cells, key players in atherosclerosis, take up and present antigens, leading to systemic and local T cell activation. The recruitment and activation of immune cells to the aorta in atherosclerosis is regulated by adhesion molecules, chemokines ...
Iuliia O. Peshkova, Aliia R. Fatkhullina, Zbigniew Mikulski, Klaus Ley, Ekaterina K. Koltsova   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source