Results 71 to 80 of about 1,918,353 (309)
PKA regulates autophagy through lipolysis during fasting
Molecules and Cells: Autophagy is a crucial intracellular degradation process that provides energy and supports nutrient deprivation adaptation. However, the mechanisms by which these cells detect lipid scarcity and regulate autophagy are poorly understood.
Yul Ji +6 more
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Reduced efficacy of a Src kinase inhibitor in crowded protein solution
Nature Communications, 2021 The intracellular compartment is a crowded environment. Here, the authors use molecular dynamics (MD) simulations to assess inhibitor binding to c-Src kinase and show how ligand binding pathways differ in crowded and dilute protein solutions ...
Kento Kasahara +10 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Microbiome, 2018 Background The ability to efficiently characterize microbial communities from host individuals can be limited by co-amplification of host organellar sequences (mitochondrial and/or plastid), which share a common ancestor and thus sequence similarity with
Connor R. Fitzpatrick +7 more
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Advanced ScienceDisulfidptosis, a newly identified form of programmed cell death, has emerged as a promising therapeutic target for tumors. However, the current research in this field is hindered by the absence of precise and quantifiable biomarkers to accurately ...
Congcong Zhang +12 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Exploring Evolution and Biology of Oomycetes: Integrative and Comparative Genomics
, 2013 Diseases that destroy livestock and crops have had catastrophic effects on human civilization, causing starvation and economical losses and continue to be a constant threat to global food production.
Sub Theoretical Biology & Bioinformatics +3 more
core
, 2014 This work was supported by grants from the NIH (R01CA86072 to R.G.P. and R01CA72038-01 to S.A.W.F.) and The Susan Komen Breast Cancer Foundation (to R.G.P.). R.T.H. and E.J. were supported by the Medical Research Council. Y.-G.Y.
Wang, Jian +13 more
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Impact of herbicides on soil biology and function [PDF]
, 2016 There is a growing awareness among farmers about the importance of soil for sustaining crop production and providing beneficial ecosystem services. Over the last 2 decades, global herbicide use has increased as farmers have shifted to more sustainable ...
Ivan R. Kennedy +26 more
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