Results 91 to 100 of about 1,826,621 (263)

WDR-5 exhibits H3K4 methylation-independent activity during embryonic development in C. elegans

Epigenetics & Chromatin
Background Histone H3 lysine 4 methylation (H3K4me) is generally associated with active transcription and bivalent chromatin but can also contribute to repression.
Nurulhafizah Binti Samsudin, Siyao Wang, Kate Fisher, Gino B. Poulin   +3 more
doaj   +1 more source

High-throughput screening of human genetic variants by pooled prime editing

Cell Genomics
Summary: Multiplexed assays of variant effect (MAVEs) enable scalable functional assessment of human genetic variants. However, established MAVEs are limited by exogenous expression of variants or constraints of genome editing.
Michael Herger, Christina M. Kajba, Megan Buckley, Ana Cunha, Molly Strom, Gregory M. Findlay   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Structure-guided screening identifies Tucatinib as dual inhibitor for MCT1/2

EMBO Reports
Cell surface glycoproteins Basigin or embigin form heterodimers with monocarboxylate transporters (MCTs), enhancing their membrane trafficking and modulating their transport functions.
Binghong Xu, Xiaoyu Zhou, Yuanyue Shan, Sai Shi, Jiachen Li, Qinqin Liang, Ziyu Wang, Mingfeng Zhang, Yaxin Wang, Duanqing Pei, Sheng Ye   +10 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. [PDF]

Circ Res, 2016
Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ, American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology.   +14 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

VHL suppresses UBE3B-mediated breast tumor growth and metastasis

Cell Death and Disease
Protein homeostasis is predominantly governed through post-translational modification (PTM). UBE3B, identified as an oncoprotein, exhibits elevated protein levels in breast cancer. However, the impact of PTM on UBE3B remains unexplored. In this study, we
Shuo Wang, Huiyan Li, Xiong Liu, Tingting Yin, Tingru Li, Miaomiao Zheng, Min Liu, Xiaoqian Meng, Jun Zhou, Yijie Wang, Yan Chen   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Looking back on 50 years of cell biology in Japan

Cell Structure and Function
Cell Structure and Function (CSF), the official journal of the Japan Society for Cell Biology (JSCB), celebrates its 50th anniversary in 2025. This essay traces the scientific evolution of CSF from its founding in 1975 to the present, drawing on ...
Michiyuki Matsuda
doaj   +1 more source