Results 81 to 90 of about 9,201,131 (312)

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

Nature Communications, 2018
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells ...
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord   +22 more
doaj   +1 more source

Introductory Biology

, 2020
7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology and genetics for understanding the functions of living systems.
Sinha, Diviya, Imperiali, Barbara, Amon, Angelika   +2 more
core  

Advances in macrophage and dendritic cell biology in HIV-1 infection stress key understudied areas in infection, pathogenesis, and analysis of viral reservoirs

, 2006
The continued quest to intervene in HIV-1 infection by halting transmission, suppressing replication, or eradicating disease in infected subjects stresses the significance of dendritic cell and macrophage biology as early and persistent players in the ...
Perno, CF, PERNO, CARLO FEDERICO, Crowe, SM, Aquaro, S, Collman, RG, Montaner, LJ, Crowe, SM, Aquaro, S, Stevenson, M   +7 more
core   +1 more source

IFPA meeting 2015 workshop report IV: Nanomedicine applications and exosome biology, xenobiotics and endocrine disruptors and pregnancy, and lipid mediators and placental function. [PDF]

, 2016
Workshops are an important part of the IFPA annual meeting, as they allow for discussion of specialized topics. At the IFPA meeting 2015 there were twelve themed workshops, three of which are summarized in this report.
Keelan, J., Albrecht, Claudia, Keelan, J, Johnstone, Edward, Vaillancourt, Cathy, Lewis, R, Murthi, P, Clifton, Vicki, Hemmings, D, Albrecht, C, Johnstone, E, Gohner, Claudia, Keelan, Jeffrey, Murthi, P., Johnstone, Ed, Saffery, R., Harris, L., Hemmings, D., Vaillancourt, C., Saffery, R, Jawerbaum, Alicia, Gohner, C, Salomon, C, Wadsack, C, Powell, Theresa, Caniggia, I., Hemmings, Denise, Salomon, C., Caniggia, Isabella, Saffery, Richard, Göhner, C., Wadsack, C., Jones, H, Jawerbaum, A, Vaillancourt, C, Albrecht, C., Harris, Lynda, Lewis, Rohan, Clifton, V., Mitchell, M., Johnstone, E., Powell, T., Murthi, Padma, Mitchell, Murray, Smith, R., Caniggia, I, Harris, Lynda K; id_orcid, Smith, R, Powell, T, Jawerbaum, A., Smith, Roger, Albrecht, Christiane, Jawerbaum, Alicia Sandra, Jones, Helen, Harris, L, Jones, H., Mitchell, M, Clifton, V, Wadsack, Christian, Lewis, R., Salomon, Carlos, Jawerbaum A, Göhner C, Hemmings D, Johnstone E, Salomon C, Saffery R, Vaillancourt C, Lewis R, Jones H, Albrecht C, Wadsack C, Clifton V, Powell T, Mitchell M, Caniggia I, Murthi P, Smith R, Harris L, Keelan J   +79 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

PKA regulates autophagy through lipolysis during fasting

Molecules and Cells
: Autophagy is a crucial intracellular degradation process that provides energy and supports nutrient deprivation adaptation. However, the mechanisms by which these cells detect lipid scarcity and regulate autophagy are poorly understood.
Yul Ji, Yong Geun Jeon, Won Taek Lee, Ji Seul Han, Kyung Cheul Shin, Jin Young Huh, Jae Bum Kim   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science
Disulfidptosis, a newly identified form of programmed cell death, has emerged as a promising therapeutic target for tumors. However, the current research in this field is hindered by the absence of precise and quantifiable biomarkers to accurately ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
doaj   +1 more source

Cell Biology

, 2023
This course deals with the biology of cells of higher organisms: The structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the ...
Ploegh, Hidde, Orr-Weaver, Terry
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source