Results 81 to 90 of about 6,642,147 (292)

Performance analysis of general purpose and digital signal processor kernels for heterogeneous systems-on-chip [PDF]

Advances in Radio Science, 2003
Various reasons like technology progress, flexibility demands, shortened product cycle time and shortened time to market have brought up the possibility and necessity to integrate different architecture blocks on one heterogeneous System-on-Chip (SoC ...
T. von Sydow, H. Blume, T. G. Noll
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Block sensitivity of weakly symmetric functions

Theoretical Computer Science, 2006
\textit{N. Nisan} [SIAM J. Comput. 20, No. 6, 999--1007 (1991; Zbl 0737.68028)] introduced the concept of block sensitivity of a Boolean function \(f\), denoted by \(\text{bs}(f)\), proved tight bounds for computing \(\text{bs}(f)\) on a CREW PRAM and showed that block sensitivity is polynomially related to many other measures of complexity.
openaire   +4 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Non-Contiguous Protein Recombination [PDF]

, 2013
Swapping sequence elements among related proteins can produce chimeric proteins with novel behaviors and improved properties such as enhanced stability. Although homologous mutations are much more conservative than random mutations, chimeras of distantly-
Smith, Matthew Alexander
core   +1 more source

Vertical deformation and tectonic activity in Tianjin area

Geodesy and Geodynamics, 2010
Vertical deformation in Tianjin area during 1992–2008 was calculated from leveling data. The effect of large surface subsidence caused by extensive groundwater pumping was removed by fitting the data along each survey line with a polynomial function. The
Liangqian Guo, Wanju Bo, Yukun Chen, Lanyu Yao, La Ta, Haitao Zhou, He Guo   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Concurrent Deterministic Execution Semantics for IEC 61499-Based OT–IT Convergence Industrial Edge Applications

IEEE Open Journal of the Industrial Electronics Society
Industrial edge computing provides new possibilities for traditional industrial automation systems. With massive computing, storage, and communication resources equipped with devices on the shop floor, a typical edge device can simultaneously handle ...
Wenbin Dai, Shang Gao, Kaiyun Qin, Chuanyang Yu, Dongdong Zhang, Likuan Zhang, Hui Zhang   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source