Results 91 to 100 of about 6,362,947 (287)
Drug Design, Development and Therapy, 2014 Jiangdong Sui,1,2 Mengxia Li,1 Chengyuan Qian,1 Shufeng Wang,3 Yi Cheng,1 Benjamin PC Chen,2 Dong Wang1 1Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of ...
Sui J +6 more
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
FLA-UNet: feature-location attention U-Net for foveal avascular zone segmentation in OCTA images
Frontiers in Artificial IntelligenceIntroductionSince optical coherence tomography angiography (OCTA) is non-invasive and non-contact, it is widely used in the study of retinal disease detection.
Wei Li, Li Cao, He Deng
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FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2015 <p>This is our first stable release. It's intended to provide a stable version of Blocks and Fuel leading up to the NIPS 2015 deadline, and as a testbed for our new development model.</p ...
Dmitry Bogdanov +13 more
core +1 more source
Symbiotic human-robot collaboration : Multimodal control using function blocks
, 2020 Complex assembly tasks require increased flexibility and adaptability, as well as higher effort on the conventional (re)programming of robots. To solve such challenges, this paper presents a function block-enabled multimodal control scheme for symbiotic ...
Wang, Xi Vincent, +2 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Towards IEC 61499 Function Blocks Diagrams Verification
, 2002 International audienceAfter having sketched the different techniques enabling to check properties of Discrete Event Systems control software, we present in this article a formal method for IEC 61499 function blocks diagrams verification.
Faure, Jean-Marc +2 more
core +1 more source