Results 81 to 90 of about 43,776 (261)

Eigenvalues of the negative Laplacian for arbitrary multiply connected domains

International Journal of Mathematics and Mathematical Sciences, 1996
The purpose of this paper is to derive some interesting asymptotic formulae for spectra of arbitrary multiply connected bounded domains in two or three dimensions, linked with variation of positive distinct functions entering the boundary conditions ...
E. M. E. Zayed
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A linear functional differential equation with distributions in the input

Electronic Journal of Differential Equations, 2003
This paper studies the functional differential equation $$ dot x(t) = int_a^t {d_s R(t,s), x(s)} + F'(t), quad t in [a,b], $$ where $F'$ is a generalized derivative, and $R(t,cdot)$ and $F$ are functions of bounded variation. A solution is defined by the
Vadim Z. Tsalyuk
doaj  

Advanced Stability Analysis of Regularized Newton Methods for Monotone Inclusions With Bounded Variation

Journal of Applied Mathematics
This paper presents a comprehensive stability analysis of regularized Newton methods for solving monotone inclusion problems of the form 0∈Ax+Fx, where A is a maximal monotone operator and F is a Lipschitz continuous operator with bounded variation.
Boushra Abbas
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

New approaches to corrected Euler–Maclaurin-type inequalities involving Riemann–Liouville fractional integrals for different function classes

Boundary Value Problems
This paper investigates several Corrected Euler–Maclaurin-type inequalities for different function classes using Riemann–Liouville fractional integrals.
Hasan Kara, Fatih Hezenci, Arslan Munir, Hüseyin Budak   +3 more
doaj   +1 more source

On the derivatives of functions of bounded variation

, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources