Results 141 to 150 of about 10,585,569 (293)
Exploring the sequence-function space of microbial fucosidases
, 2023 Gascueña AM +13 more
europepmc +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Definability in function spaces
, 2000 Let \(X\), \(Y\) denote Polish spaces. Let us recall that a~set \(A\subseteq X\) is wedge reducible to \(B\subseteq Y\) if there is a~continuous function \(f:X\to Y\) such that \(A=f^{-1}(B)\). Wedge reducibility is a~preordering and the classes of equivalences induced by this preordering are called wedge degrees.
ANDRETTA, Alessandro, MARCONE ALBERTO
openaire +3 more sources
Function space topologies - The graph topology [PDF]
, 1969 Function space topologies-graph ...
Bracken, P. A.
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 1998 Catalogue of an exhibition held at Canberra Contemporary Art Space, A.C.T., 28 February - 22 March 1998.Art of Jacqueline Fraser, Kelly Thompson, Yuk King Tan & Ani O'Neill.Curator: Melissa ...
Canberra Contemporary Art Space
core
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
, 2008 This contribution considers nonlinear space–time equalisation (STE) for multiple receive-antenna induced single-input multipleoutput (SIMO) systems. By exploiting the inherent symmetry of the underlying optimal Bayesian STE solution, a novel symmetric ...
Liu, Sheng, Chen, Sheng, Hanzo, Lajos
core +1 more source
A duality in function spaces [PDF]
Transactions of the American Mathematical Society, 1965 openaire +2 more sources