Results 61 to 70 of about 6,309,373 (323)
, 2013 In this paper we introduce a generalized Sobolev space by defining a semi-inner product formulated in terms of a vector distributional operator $\mathbf{P}$ consisting of finitely or countably many distributional operators $P_n$, which are defined on the
A. Berlinet +19 more
core +1 more source
Calculus and fine properties of functions of bounded variation on RCD spaces [PDF]
, 2022 Camillo Brena, Nicola Gigli
openalex +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Local function conservation in sequence and structure space. [PDF]
PLoS Computational Biology, 2008 We assess the variability of protein function in protein sequence and structure space. Various regions in this space exhibit considerable difference in the local conservation of molecular function.
Nils Weinhold +4 more
doaj +1 more source
On the $C_k$-stable closure of the class of (separable) metrizable spaces
, 2015 Denote by $\mathbf C_k[\mathfrak M]$ the $C_k$-stable closure of the class $\mathfrak M$ of all metrizable spaces, i.e., $\mathbf C_k[\mathfrak M]$ is the smallest class of topological spaces that contains $\mathfrak M$ and is closed under taking ...
Banakh, Taras, Gabriyelyan, Saak
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Noncritical holomorphic functions on Stein spaces
, 2015 We prove that every reduced Stein space admits a holomorphic function without critical points. Furthermore, any closed discrete subset of such a space is the critical locus of a holomorphic function.
Forstneric, Franc
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source