Results 81 to 90 of about 1,366,798 (265)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature. [PDF]

Biol Direct, 2023
Tantoso E, Eisenhaber B, Sinha S, Jensen LJ, Eisenhaber F.   +4 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Reflections on function spaces

Annals of Pure and Applied Logic, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Characterisation of sequence-structure-function space in sensor-effector integrators of phytochrome-regulated diguanylate cyclases. [PDF]

Photochem Photobiol Sci, 2022
Böhm C, Gourinchas G, Zweytick S, Hujdur E, Reiter M, Trstenjak S, Sensen CW, Winkler A.   +7 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Phosphine Depletion in Brown Dwarf Atmospheres Explained due to Metal Phosphide Formation

The Astrophysical Journal Letters
Phosphine (PH _3 ) is predicted to be the dominant phosphorus-bearing gas in cool substellar atmospheres, yet observations have revealed a puzzling pattern.
Rongzhang Yin, Yan Li, Yanzhang Li, Sara Seager   +3 more
doaj   +1 more source

RadicalSAM.org: A Resource to Interpret Sequence-Function Space and Discover New Radical SAM Enzyme Chemistry. [PDF]

ACS Bio Med Chem Au, 2022
Oberg N, Precord TW, Mitchell DA, Gerlt JA.   +3 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source