Results 101 to 110 of about 11,568 (285)

Recent Advances in Amyloids Structural Studies and Thin Film Applications

Molecules
Amyloids are protein-based biomaterials composed of fibrils with cross-β cores. Previously only associated with degenerative diseases, such as Parkinson’s disease, Alzheimer’s disease, and diabetes, amyloids remain active and functional both in vivo and ...
Eugenia Pechkova, Stefano Fiordoro, Alberto Izzotti, Christian Riekel   +3 more
doaj   +1 more source

Meta-structure correlation in protein space unveils different selection rules for folded and intrinsically disordered proteins [PDF]

, 2012
The number of existing protein sequences spans a very small fraction of sequence space. Natural proteins have overcome a strong negative selective pressure to avoid the formation of insoluble aggregates.
Campen, Coeytaux, Dosztanyi, Dunker, Dyson, Gsponer, Ishida, Konrat, Lieutaud, Linding, Linking, Lise, Maurer-Stroh, Miquel Pons, Obradovic, Olzscha, Prilusky, Robert Konrat, Sickmeier, Tompa, Tompa, Vucetic, Ward, Xie, Yandi Naranjo, Yang   +25 more
core   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source

Physical Determinants of Amyloid Assembly in Biofilm Formation

mBio, 2019
A wide range of bacterial pathogens have been shown to form biofilms, which significantly increase their resistance to environmental stresses, such as antibiotics, and are thus of central importance in the context of bacterial diseases.
Maria Andreasen, Georg Meisl, Jonathan D. Taylor, Thomas C. T. Michaels, Aviad Levin, Daniel E. Otzen, Matthew R. Chapman, Christopher M. Dobson, Steve J. Matthews, Tuomas P. J. Knowles   +9 more
doaj   +1 more source

Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy [PDF]

, 2015
Altres ajuts: FISS/PS09-00165Altres ajuts: FISS/PI12-00327Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent.
Corchero Nieto, José Luis, Ferrer-Miralles, Neus, Garcia-Fruitos, Elena, Rodríguez-Carmona, Escarlata, Villaverde Corrales, Antonio, Vázquez Gómez, Esther   +5 more
core   +2 more sources

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+] [PDF]

, 2009
Prions are proteins that can access multiple conformations, at least one of which is beta-sheet rich, infectious and self-perpetuating in nature. These infectious proteins show several remarkable biological activities, including the ability to form ...
A Aguzzi, A Brachmann, A Kishimoto, A Romanelli, A Santoso, AF Hill, AH DePace, AJ Ball, AV Kajava, B Caughey, B Chen, BH Toyama, BK Patel, BK Patel, C Resende, C Vital, CY King, CY King, DA Kocisko, DJ Selkoe, DM Fowler, DM Fowler, DM Walsh, E Cohen, ED Ross, F Shewmaker, G Legname, GM Shankar, HL True, HL True, HY Chang, HY Lian, IL Derkatch, IL Derkatch, IL Derkatch, IV Baskakov, J Collinge, J Collinge, J Collinge, J Krzewska, J Nemecek, J Safar, J Shorter, J Shorter, J Shorter, J Tyedmers, JJ Liu, JP Cleary, JR Glover, JR Glover, K Iwata, K Si, KA Dill, KV Volkov, L Li, LC Serpell, LZ Osherovich, M Bruce, M Scott, M Tanaka, M Tanaka, M Tanaka, MD Michelitsch, MD Ter-Avanesyan, MD Yoder, ME Bruce, MF Tuite, ML Maddelein, MM Patino, MM Patino, MR Chapman, MR Sawaya, N Sondheimer, NR Deleault, OS Makin, P Chien, P Chien, P Chien, P Collin, P Silar, PC van der Wel, Peter M Tessier, PM Tessier, R Diaz-Avalos, R Kayed, R Krishnan, R Nelson, R Nelson, R Wetzel, RA Bessen, RB Wickner, RB Wickner, RB Wickner, RB Wickner, S Alberti, S Catharino, S Lesné, S Lindquist, S Mukhopadhyay, S Shivaprasad, S Supattapone, SB Prusiner, SB Prusiner, SB Prusiner, SL Crick, SM Uptain, SN Parham, SR Collins, SS Eaglestone, Susan Lindquist, SV Paushkin, SV Paushkin, T Nakayashiki, T Scheibel, T Scheibel, TR Serio, TW Muir, V Coustou, V Coustou, VV Kushnirov, WA Voter, YO Chernoff, YO Chernoff, Z Du, Z Tallóczy   +124 more
core   +2 more sources

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

The proteostasis network and its decline in ageing

, 2019
Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source