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Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]
PrionThe FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina +7 more
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Electrostatic interactions mediate the nucleation and growth of a bacterial functional amyloid [PDF]
Frontiers in Molecular Biosciences, 2023 Bacterial biofilm formation can have severe impacts on human and environmental health. Enteric bacteria produce functional amyloid fibers called curli that aid in biofilm formation and host colonization. CsgA is the major proteinaceous component of curli
Sujeet S. Bhoite +3 more
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Functional Mammalian Amyloids and Amyloid-Like Proteins [PDF]
Life, 2020 Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel +6 more
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Prion, 2010 Evidence is growing at an increasing -pace that amyloid fibers are not just the result of aberrant protein folding associated with neurodegenerative diseases, but are widespread in nature for beneficial reasons. Amyloid is an attractive building material because its robust design and simple repetitive structure make for very durable and metabolically ...
Daniel E. Otzen
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Why are Functional Amyloids Non-Toxic in Humans? [PDF]
Biomolecules, 2017 Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in ...
Matthew P. Jackson, Eric W. Hewitt
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Tuning Functional Amyloid Formation Through Disulfide Engineering [PDF]
Frontiers in Microbiology, 2020 Many organisms produce “functional” amyloid fibers, which are stable protein polymers that serve many roles in cellular biology. Certain Enterobacteriaceae assemble functional amyloid fibers called curli that are the main protein component of the biofilm
Anthony Balistreri +3 more
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Amyloid Imaging in Aging and Dementia: Testing the Amyloid Hypothesis In Vivo [PDF]
Behavioural Neurology, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
G. D. Rabinovici, W. J. Jagust
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Zinc–dysprosium functionalized amyloid fibrils [PDF]
Dalton Transactions, 2019 The heterometallic Zn2Dy2 entity bearing partially saturated metal centres covalently decorates a highly ordered amyloid fibril core and the functionalised assembly exhibits catalytic Lewis acid behaviour.
Stavroula I. Sampani +4 more
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The emerging concept of functional amyloid [PDF]
Journal of Internal Medicine, 2009 Abstract.Although amyloid has usually been considered a pathological structure, growing evidence indicates that amyloid may also be a productive part of cell biology contributing to normal physiology. In fact, amyloid formation seems to be an intrinsic propensity of polypeptides in general and the amyloid β‐fold an evolutionary highly conserved ...
C. P. J. Maury
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Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid [PDF]
Advanced ScienceUnderstanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of
Yue Wang +10 more
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