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Functional Mammalian Amyloids and Amyloid-Like Proteins [PDF]

Life, 2020
Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel, Sergey A. Fedotov, Anastasia V. Grizel, Julia V. Sopova, Oksana A. Malikova, Yury O. Chernoff, Aleksandr A. Rubel   +6 more
doaj   +5 more sources

Electrostatic interactions mediate the nucleation and growth of a bacterial functional amyloid [PDF]

Frontiers in Molecular Biosciences, 2023
Bacterial biofilm formation can have severe impacts on human and environmental health. Enteric bacteria produce functional amyloid fibers called curli that aid in biofilm formation and host colonization. CsgA is the major proteinaceous component of curli
Sujeet S. Bhoite, Divya Kolli, Mark A. Gomulinski, Matthew R. Chapman   +3 more
doaj   +2 more sources

Tuning Functional Amyloid Formation Through Disulfide Engineering [PDF]

Frontiers in Microbiology, 2020
Many organisms produce “functional” amyloid fibers, which are stable protein polymers that serve many roles in cellular biology. Certain Enterobacteriaceae assemble functional amyloid fibers called curli that are the main protein component of the biofilm
Anthony Balistreri, Ethan Kahana, Soorya Janakiraman, Matthew R. Chapman   +3 more
doaj   +2 more sources

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +2 more sources

Why are Functional Amyloids Non-Toxic in Humans?

Biomolecules, 2017
Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in ...
Matthew P. Jackson, Eric W. Hewitt
doaj   +3 more sources

Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid [PDF]

Advanced Science
Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of
Yue Wang, Xiufang Liang, Nicholas Andrikopoulos, Huayuan Tang, Fei He, Xiang Yin, Yuhuan Li, Feng Ding, Guotao Peng, Monika Mortimer, Pu Chun Ke   +10 more
doaj   +2 more sources

Direct Identification of Functional Amyloid Proteins by Label-Free Quantitative Mass Spectrometry

Biomolecules, 2017
Functional amyloids are important structural and functional components of many biofilms, yet our knowledge of these fascinating polymers is limited to a few examples for which the native amyloids have been isolated in pure form.
Heidi N. Danielsen, Susan H. Hansen, Florian-Alexander Herbst, Henrik Kjeldal, Allan Stensballe, Per H. Nielsen, Morten S. Dueholm   +6 more
doaj   +3 more sources

The Amyloid Region of Hfq Riboregulator Promotes DsrA:rpoS RNAs Annealing

Biology, 2021
Hfq is a bacterial RNA chaperone which promotes the pairing of small noncoding RNAs to target mRNAs, allowing post-transcriptional regulation. This RNA annealing activity has been attributed for years to the N-terminal region of the protein that forms a ...
Florian Turbant, Pengzhi Wu, Frank Wien, Véronique Arluison   +3 more
doaj   +1 more source

Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq

Antibiotics, 2021
Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance
Florian Turbant, David Partouche, Omar El Hamoui, Sylvain Trépout, Théa Legoubey, Frank Wien, Véronique Arluison   +6 more
doaj   +1 more source

Sticking to the Subject: Multifunctionality in Microbial Adhesins

Journal of Fungi, 2023
Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and adhesion to host. We divide these proteins into two major classes: professional adhesins and moonlighting adhesins that have a non-adhesive activity that is ...
Peter N. Lipke, Peleg Ragonis-Bachar
doaj   +1 more source