Results 11 to 20 of about 3,632,451 (277)

Functional Amyloids [PDF]

Cold Spring Harbor Perspectives in Biology, 2019
When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire   +4 more sources

Amyloids: The History of Toxicity and Functionality [PDF]

Biology, 2021
Proteins can perform their specific function due to their molecular structure. Partial or complete unfolding of the polypeptide chain may lead to the misfolding and aggregation of proteins in turn, resulting in the formation of different structures such as amyloid aggregates.
Elmira I. Yakupova, Liya G. Bobyleva, Sergey A. Shumeyko, Ivan M. Vikhlyantsev, Alexander G. Bobylev   +4 more
openaire   +3 more sources

Structural Studies of Cystatin B Amyloid Fibre and Oligomer [PDF]

, 2013
Amyloid fibres are characteristic of over 25 degenerative human diseases including Alzheimer’s and Parkinson’s disease. Amyloid fibres are insoluble, highly stable, ordered cross-β sheet structures, which form as a result of conformational change and ...
Davis, Peter J.
core   +5 more sources

Functional Amyloids in Reproduction [PDF]

Biomolecules, 2017
Amyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes.
Hewetson, Aveline, Do, Hoa Quynh, Myers, Caitlyn, Muthusubramanian, Archana, Sutton, Roger Bryan, Wylie, Benjamin J., Cornwall, Gail A.   +6 more
openaire   +2 more sources

Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]

, 2011
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory, Catherine Parr-Sturgess, Parr-Sturgess, Catherine, Edward Parkin, Mallory Gough, Parkin, Edward   +5 more
core   +5 more sources

Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins

Molecules, 2021
The ancient paralogs premelanosome protein (PMEL) and glycoprotein nonmetastatic melanoma protein B (GPNMB) have independently emerged as intriguing disease loci in recent years.
Paul W. Chrystal, Tim Footz, Elizabeth D. Hodges, Justin A. Jensen, Michael A. Walter, W. Ted Allison   +5 more
doaj   +1 more source

Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants

Frontiers in Molecular Biosciences, 2022
Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione, Rossana Pitocchi, Anna Pennacchio, Paola Cicatiello, Alessandra Piscitelli, Paola Giardina   +5 more
doaj   +1 more source

Fibrilar Polymorphism of the Bacterial Extracellular Matrix Protein TasA

Microorganisms, 2021
Functional amyloid proteins often appear as fibers in extracellular matrices of microbial soft colonies. In contrast to disease-related amyloid structures, they serve a functional goal that benefits the organism that secretes them, which is the reason ...
Mnar Ghrayeb, Shahar Hayet, Neta Lester-Zer, Yael Levi-Kalisman, Liraz Chai   +4 more
doaj   +1 more source

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis [PDF]

, 2013
Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem
Rafael Delgado Y Palacios, Christian Bigot, Van Der Linden, Anne-Marie, Bigot, Christian, Van der Linden, Annemie, Rafael Delgado y Palacios (498616), Verhoye, Marleen, Disha Shah, Annemie Van der Linden, Christian Bigot (498617), Dany V D'Souza, Shah, Disha, Disha Shah (498613), Annemie Van der Linden (2227165), Elisabeth Jonckers, D'Souza, Dany V., Greetje Vanhoutte, Jonckers, Elisabeth, Jelle Praet (498614), Delgado y Palacios, Rafael, Greetje Vanhoutte (498615), Marleen Verhoye, Praet, Jelle, Marleen Verhoye (95635), Vanhoutte, Greetje, Jelle Praet, Elisabeth Jonckers (353117), Dany V. D’Souza (498618), Delgado y Palacios Rafael, Van der Linden Annemie, Bigot Christian, Praet Jelle, Shah Disha, D’Souza Dany V., Verhoye Marleen, Vanhoutte Greetje, Jonckers Elisabeth   +36 more
core   +2 more sources

Serum Amyloid P Component Binds Fungal Surface Amyloid and Decreases Human Macrophage Phagocytosis and Secretion of Inflammatory Cytokines

mBio, 2019
In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the ...
Nicole E. Behrens, Peter N. Lipke, Darrell Pilling, Richard H. Gomer, Stephen A. Klotz   +4 more
doaj   +1 more source