Results 11 to 20 of about 308,404 (341)
Functional Amyloid Formation within Mammalian Tissue.
PLoS Biology, 2005 Amyloid is a generally insoluble, fibrous cross-beta sheet protein aggregate. The process of amyloidogenesis is associated with a variety of neurodegenerative diseases including Alzheimer, Parkinson, and Huntington disease.
Douglas M Fowler +5 more
doaj +6 more sources
Functional Coating from Amyloid Superwetting Films
Advanced Materials, 2022 AbstractTailoring the hydrophilicity of solid surfaces with a strong affinity to water has been extensively explored in the last 20 years, but studies have been limited to the single function of wettability. Here, the multifunctional properties of tailored surface films are extended from exhibiting superwettability to facilitating biological activities.
Tonghui Jin +5 more
openaire +5 more sources
Quantitating denaturation by formic acid: imperfect repeats are essential to the stability of the functional amyloid protein FapC. [PDF]
J Biol Chem, 2020 Christensen LFB +4 more
europepmc +3 more sources
The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties. [PDF]
J Biol ChemSachan S +7 more
europepmc +3 more sources
The Amyloid Region of Hfq Riboregulator Promotes DsrA:rpoS RNAs Annealing
Biology, 2021 Hfq is a bacterial RNA chaperone which promotes the pairing of small noncoding RNAs to target mRNAs, allowing post-transcriptional regulation. This RNA annealing activity has been attributed for years to the N-terminal region of the protein that forms a ...
Florian Turbant +3 more
doaj +1 more source
Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq
Antibiotics, 2021 Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance
Florian Turbant +6 more
doaj +1 more source
Functional Domains and Evolutionary History of the PMEL and GPNMB Family Proteins
Molecules, 2021 The ancient paralogs premelanosome protein (PMEL) and glycoprotein nonmetastatic melanoma protein B (GPNMB) have independently emerged as intriguing disease loci in recent years.
Paul W. Chrystal +5 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2019 When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are usually associated with disease including Alzheimer's. However, amyloid has many useful features.
Otzen, Daniel, Riek, Roland
openaire +3 more sources
Innovative surface bio-functionalization by fungal hydrophobins and their engineered variants
Frontiers in Molecular Biosciences, 2022 Research on innovative surface functionalization strategies to develop materials with high added value is particularly challenging since this process is a crucial step in a wide range of fields (i.e., biomedical, biosensing, and food packaging).
Ilaria Stanzione +5 more
doaj +1 more source
Fibrilar Polymorphism of the Bacterial Extracellular Matrix Protein TasA
Microorganisms, 2021 Functional amyloid proteins often appear as fibers in extracellular matrices of microbial soft colonies. In contrast to disease-related amyloid structures, they serve a functional goal that benefits the organism that secretes them, which is the reason ...
Mnar Ghrayeb +4 more
doaj +1 more source