Results 21 to 30 of about 308,404 (341)
Anti-Biofilm Molecules Targeting Functional Amyloids [PDF]
Antibiotics, 2021 The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing structural components of the biofilm matrix in a wide range of bacteria.
Leticia Matilla-Cuenca +2 more
openaire +6 more sources
Functional Amyloids in Reproduction [PDF]
Biomolecules, 2017 Amyloids are traditionally considered pathological protein aggregates that play causative roles in neurodegenerative disease, diabetes and prionopathies. However, increasing evidence indicates that in many biological systems nonpathological amyloids are formed for functional purposes.
Hewetson, Aveline +6 more
openaire +2 more sources
Sticking to the Subject: Multifunctionality in Microbial Adhesins
Journal of Fungi, 2023 Bacterial and fungal adhesins mediate microbial aggregation, biofilm formation, and adhesion to host. We divide these proteins into two major classes: professional adhesins and moonlighting adhesins that have a non-adhesive activity that is ...
Peter N. Lipke, Peleg Ragonis-Bachar
doaj +1 more source
The relationship between amyloid structure and cytotoxicity [PDF]
, 2014 Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo +3 more
core +1 more source
mBio, 2019 In patients with invasive fungal diseases, there is often little cellular inflammatory response. We tested the idea that binding of the human constitutive plasma protein serum amyloid P component (SAP) (also called PTX2) to Candida albicans dampens the ...
Nicole E. Behrens +4 more
doaj +1 more source
Microorganisms, 2021 The pathogen Staphylococcus aureus is recognized as one of the most frequent causes of biofilm-associated infections. The recently identified phenol-soluble modulin (PSM) peptides act as the key molecular effectors of staphylococcal biofilm maturation ...
Masihuz Zaman, Maria Andreasen
doaj +1 more source
Using the A/T/N framework to examine driving in preclinical Alzheimer’s disease [PDF]
, 2018 The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years.
Ances, Beau M +9 more
core +3 more sources
Unzipping a Functional Microbial Amyloid [PDF]
ACS Nano, 2012 Bacterial and fungal species produce some of the best-characterized functional amyloids, that is, extracellular fibres that play key roles in mediating adhesion and biofilm formation. Yet, the molecular details underlying their mechanical strength remain poorly understood.
David, Alsteens +3 more
openaire +2 more sources
Genes Involved in Biofilm Matrix Formation of the Food Spoiler Pseudomonas fluorescens PF07
Frontiers in Microbiology, 2022 The extracellular matrix is essential for the biofilm formation of food spoilers. Pseudomonas fluorescens PF07 is a previous isolate from spoiled marine fish; however, the genes involved in the extracellular matrix formation of PF07 biofilms remain ...
Miao Guo +7 more
doaj +1 more source
Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative. [PDF]
, 2018 IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker ...
Aisen, Paul S +5 more
core +1 more source