Results 41 to 50 of about 3,632,451 (277)

Injectable Peptide-Based Functional Amyloid Hydrogels as Tunable Depots for Sustained Drug Delivery. [PDF]

Adv Sci (Weinh)
An injectable and tunable peptide‐based functional amyloid hydrogel provides sustained insulin release while preserving insulin stability and bioactivity. The hydrogel enables prolonged glycemic regulation in vivo, exhibits excellent biocompatibility, and shows no detectable IAPP and α‐Syn heterologous cross‐seeding, highlighting its potential as a ...
Shaw R, Chimthanawala NMA, Manna S, Sathaye S, Maji SK.   +4 more
europepmc   +2 more sources

Amyloid-Beta Influences Memory via Functional Connectivity During Memory Retrieval in Alzheimer's Disease

Frontiers in Aging Neuroscience, 2021
Objective: Amnesia in Alzheimer's disease (AD) appears early and could be caused by encoding deficiency, consolidation dysfunction, and/or impairment in the retrieval of stored memory information. The relationship between AD pathology biomarker β-amyloid
Binyin Li, Miao Zhang, Ikbeom Jang, Ikbeom Jang, Guanyu Ye, Liche Zhou, Guiying He, Xiaozhu Lin, Hongping Meng, Xinyun Huang, Wangxi Hai, Shengdi Chen, Biao Li, Biao Li, Jun Liu   +14 more
doaj   +1 more source

Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

eLife, 2022
Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid aggregation are well evident in various neurological disorders including Alzheimer’s disease.
Debdeep Chatterjee, Reeba S Jacob, Soumik Ray, Ambuja Navalkar, Namrata Singh, Shinjinee Sengupta, Laxmikant Gadhe, Pradeep Kadu, Debalina Datta, Ajoy Paul, Sakunthala Arunima, Surabhi Mehra, Chinmai Pindi, Santosh Kumar, Praful Singru, Sanjib Senapati, Samir K Maji   +16 more
doaj   +1 more source

Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival

Pathogens, 2018
Hfq is a pleiotropic regulator that has key roles in the control of genetic expression. The protein noticeably regulates translation efficiency and RNA decay in Gram-negative bacteria, due to the Hfq-mediated interaction between small regulatory ...
David Partouche, Florian Turbant, Omar El Hamoui, Camille Campidelli, Marianne Bombled, Sylvain Trépout, Frank Wien, Véronique Arluison   +7 more
doaj   +1 more source

Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization

, 2013
Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's ...
Cheaveau, M., Morgan, William, Cheaveau, Matthew, Boche, Delphine, Bharambe, V., Holmes, C., Love, S., Nicoll, James A R, Harris, Scott, Bharambe, Viraj, Neal, James W, Love, Seth, Nicoll, J.A.R., Zotova, E., Boche, D., Morgan, W., Neal, J.W., Holmes, Clive, Zotova, Elina   +18 more
core   +1 more source

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]

, 2012
Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
core   +5 more sources

Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia [PDF]

, 2001
Familial British dementia (FBD), pathologically characterized by cerebral amyloid angiopathy (CAA), amyloid plaques, and neurofibrillary degeneration, is associated with a stop codon mutation in the BRI gene resulting in the production of an ...
Tammaryn Lashley, Ghiso, J, Vidal, R, Ayling, H., Gibb, G, Anderton, B H, Hilary Ayling, Rostagno, A., Anderton, B.H., Plant, G., Janice L. Holton, Tamas Revesz, Revesz, T, Martinian, L, Henry Houlden, Ruben Vidal, Nicholas W. Wood, Lashley, T, Revesz, T., Frangione, B., Jorge Ghiso, Ayling, H, Holton, J.L., Christopher J. Guerin, Houlden, H, Plant, G, Holton, J L, Gordon Plant, Rostagno, A, Lashle, T., Gibb, G., Lillian Martinian, Ghiso, J., Graham Gibb, Martinian, L., Brian H. Anderton, Agueda Rostagno, Houlden, H., Wood, N.W., Frangione, B, Vidal, R., Guerin, C J, Wood, N W, Guerin, C.J., Blas Frangione   +44 more
core   +1 more source

Prions, prionoid complexes and amyloids: the bad, the good and something in between

Swiss Medical Weekly, 2017
Prions are infectious agents causing transmissible spongiform encephalopathies in humans and animals. These protein-based particles template conformational changes in a host-encoded prion protein to an insoluble self-like conformation.
Iva Hafner-Bratkovič
doaj   +1 more source

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly [PDF]

, 2008
Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid results in numerous human diseases. Despite an increasing number of proteins and peptide fragments being recognised as amyloidogenic, how these amyloid aggregates ...
Xue, Wei-Feng, Radford, Sheena E., Homans, Steve W.   +2 more
core   +1 more source