Results 1 to 10 of about 11,537 (252)

Structural analysis and architectural principles of the bacterial amyloid curli

Nature Communications, 2023
Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel, Brajabandhu Pradhan, Alexander N. Volkov, Han Remaut   +3 more
doaj   +2 more sources

Differential regulatory control of curli (csg) gene expression in Salmonella enterica serovar Typhi requires more than a functional CsgD regulator

Scientific Reports, 2023
The human-specific Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a systemic disease with no known reservoir. Curli fimbriae are major components of biofilm produced by Salmonella and are encoded by the csg gene cluster (csgBAC and ...
Camille Ou, Charles M. Dozois, France Daigle   +2 more
doaj   +2 more sources

In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.

PLoS Pathogens, 2020
Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica.
Amanda L Miller, J Alex Pasternak, Nicole J Medeiros, Lauren K Nicastro, Sarah A Tursi, Elizabeth G Hansen, Ryan Krochak, Akosiererem S Sokaribo, Keith D MacKenzie, Melissa B Palmer, Dakoda J Herman, Nikole L Watson, Yi Zhang, Heather L Wilson, R Paul Wilson, Aaron P White, Çagla Tükel   +16 more
doaj   +1 more source

Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion

Nature Communications, 2023
Curli are functional amyloids present on the outer membrane of E. coli. CsgF is required for the proper assembly of curli. Here, we found that the CsgF phase separates in vitro and that the ability of CsgF variants to phase-separate is tightly correlated
Hema M. Swasthi, Joseph L. Basalla, Claire E. Dudley, Anthony G. Vecchiarelli, Matthew R. Chapman   +4 more
doaj   +1 more source

Wavy or curly? [PDF]

MRS Bulletin, 2022
Graphical abstract
openaire   +3 more sources

The bacterial amyloid curli is associated with urinary source bloodstream infection. [PDF]

PLoS ONE, 2014
Urinary tract infections are the most common cause of E. coli bloodstream infections (BSI) but the mechanism of bloodstream invasion is poorly understood.
Chia Hung, Jonas Marschall, Carey-Ann D Burnham, Albert S Byun, Jeffrey P Henderson   +4 more
doaj   +1 more source

Modulating bacterial and gut mucosal interactions with engineered biofilm matrix proteins

Scientific Reports, 2018
Extracellular appendages play a significant role in mediating communication between bacteria and their host. Curli fibers are a class of bacterial fimbria that is highly amenable to engineering.
Anna M. Duraj-Thatte, Pichet Praveschotinunt, Trevor R. Nash, Frederick R. Ward, Neel S. Joshi   +4 more
doaj   +1 more source

Microanatomy at Cellular Resolution and Spatial Order of Physiological Differentiation in a Bacterial Biofilm

mBio, 2013
Bacterial biofilms are highly structured multicellular communities whose formation involves flagella and an extracellular matrix of adhesins, amyloid fibers, and exopolysaccharides.
Diego O. Serra, Anja M. Richter, Gisela Klauck, Franziska Mika, Regine Hengge   +4 more
doaj   +1 more source

Selective inhibition of the amyloid matrix of Escherichia coli biofilms by a bifunctional microbial metabolite

npj Biofilms and Microbiomes, 2023
The propensity of bacteria to grow collectively in communities known as biofilms and their ability to overcome clinical treatments in this condition has become a major medical problem, emphasizing the need for anti-biofilm strategies.
Estefanía Cordisco, María Inés Zanor, Diego Martín Moreno, Diego Omar Serra   +3 more
doaj   +1 more source

bolA gene involved in curli amyloids and fimbriae production in E. coli: exploring pathways to inhibit biofilm and amyloid formation

Journal of Biological Research - Thessaloniki, 2020
Background Biofilm formation is a complex phenomenon of bacterial cells, involved in several human infections. Its formation is regulated and controlled by several protein factors.
Mohd W. Azam, Azna Zuberi, Asad U. Khan
doaj   +1 more source