Results 21 to 30 of about 11,537 (252)

Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27

Gut Microbes
Salmonella enterica serovar Typhimurium (STm) causes gastroenteritis and can progress to reactive arthritis (ReA). STm forms biofilms in the gut that secrete the amyloid curli, which we previously demonstrated can trigger autoimmunity in mice. HLA-B27 is
Kaitlyn Grando, Shingo Bessho, Kayla Harrell, Kathrine Kyrylchuk, Alejandro M. Pantoja, Sophia Olubajo, Francisco J. Albicoro, Andres Klein-Szanto, Çagla Tükel   +8 more
doaj   +2 more sources

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation [PDF]

mBio, 2018
Curli amyloid fibers are produced as part of the extracellular biofilm matrix and are composed primarily of the major structural subunit CsgA. The CsgE chaperone facilitates the secretion of CsgA through CsgG by forming a cap at the base of the nonameric
Roger D. Klein, Qin Shu, Zachary T. Cusumano, Kanna Nagamatsu, Nathaniel C. Gualberto, Aaron J. L. Lynch, Chao Wu, Wenjie Wang, Neha Jain, Jerome S. Pinkner, Gaya K. Amarasinghe, Scott J. Hultgren, Carl Frieden, Matthew R. Chapman   +13 more
doaj   +3 more sources

Overexpression of Outer Membrane Protein X (OmpX) Compensates for the Effect of TolC Inactivation on Biofilm Formation and Curli Production in Extraintestinal Pathogenic Escherichia coli (ExPEC)

Frontiers in Cellular and Infection Microbiology, 2018
Our previous study showed that the inactivation of the efflux pump TolC could abolish biofilm formation and curli production of extraintestinal pathogenic Escherichia coli (ExPEC) strain PPECC42 under hyper-osmotic conditions.
Qi Huang, Mei Liu, Shao-Wen Li
exaly   +3 more sources

Serum Amyloid A3 Fuels a Feed-Forward Inflammatory Response to the Bacterial Amyloid Curli in the Enteric Nervous SystemSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Mounting evidence suggests the gastrointestinal microbiome is a determinant of peripheral immunity and central neurodegeneration, but the local disease mechanisms remain unknown.
Peter Verstraelen, Samuel Van Remoortel, Nouchin De Loose, Rosanne Verboven, Gerardo Garcia-Diaz Barriga, Anne Christmann, Manuela Gries, Shingo Bessho, Jing Li, Carmen Guerra, Çagla Tükel, Sales Ibiza Martinez, Karl-Herbert Schäfer, Jean-Pierre Timmermans, Winnok H. De Vos   +14 more
doaj   +2 more sources

Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS

Scientific Reports, 2023
The gut microbiome is a potential non-genetic contributing factor for Amyotrophic Lateral Sclerosis. Differences in gut microbial communities have been detected between ALS subjects and healthy controls, including an increase in Escherichia coli in ALS ...
Zimple Kurlawala, Joseph D. McMillan, Richa A. Singhal, Johnny Morehouse, Darlene A. Burke, Sophia M. Sears, Eleonora Duregon, Levi J. Beverly, Leah J. Siskind, Robert P. Friedland   +9 more
doaj   +2 more sources

Cyclic‐di‐GMP signalling and biofilm‐related properties of the Shiga toxin‐producing 2011 German outbreak Escherichia coli O104:H4 [PDF]

EMBO Molecular Medicine, 2014
In 2011, nearly 4,000 people in Germany were infected by Shiga toxin (Stx)‐producing Escherichia coli O104:H4 with > 22% of patients developing haemolytic uraemic syndrome (HUS).
Anja M Richter, Tatyana L Povolotsky, Lothar H Wieler, Regine Hengge   +3 more
doaj   +2 more sources

Assembly of ordered DNA-curli fibril complexes during Salmonella biofilm formation correlates with strengths of the type I interferon and autoimmune responses.

PLoS Pathogens, 2022
Deposition of human amyloids is associated with complex human diseases such as Alzheimer's and Parkinson's. Amyloid proteins are also produced by bacteria.
Lauren K Nicastro, Jaime de Anda, Neha Jain, Kaitlyn C M Grando, Amanda L Miller, Shingo Bessho, Stefania Gallucci, Gerard C L Wong, Çagla Tükel   +8 more
doaj   +1 more source

Curli Production Influences Cross-contamination by Escherichia coli O157:H7 When Washing Fresh-cut Romaine Lettuce

Journal of Food Protection, 2023
Escherichia coli O157:H7 expresses extracellular proteins called curli that are essential for surface colonization. Transfer rates of E. coli O157:H7 0018+ (curli+), and 0018- (curli−) from inoculated to noninoculated lettuce pieces during washing were ...
Ann Charles Vegdahl, Donald W. Schaffner
doaj   +1 more source

Serrapeptase Eliminates <i>Escherichia coli</i> Biofilms by Targeting Curli Fibers, Lipopolysaccharides, and Phosphate Metabolism. [PDF]

Microorganisms
Escherichia coli biofilms are implicated in the development of persistent infections and increased antibiotic resistance, posing a significant challenge in clinical settings.
Katsipis G, Aivaliotis M, Pantazaki AA.
europepmc   +2 more sources

Curly Questions [PDF]

Twin Research and Human Genetics, 2020
AbstractThis letter reflects on my collaborations with Nick Martin over the past 18 years. Working together we have applied twin-family and statistical genetics methods to examine the genetic architecture and identify genetic variants influencing a range of physical, psychological and social traits.
openaire   +3 more sources