Absence of Curli in Soil-Persistent Escherichia coli Is Mediated by a C-di-GMP Signaling Defect and Suggests Evidence of Biofilm-Independent Niche Specialization [PDF]
Frontiers in Microbiology, 2018 Escherichia coli is commonly viewed as a gastrointestinal commensal or pathogen although an increasing body of evidence suggests that it can persist in non-host environments as well.
Yinka M. Somorin +6 more
doaj +6 more sources
Microorganisms, 2020 Escherichia coli O157:H7 (O157) is noninvasive and a weak biofilm producer; however, a subset of O157 are exceptions. O157 ATCC 43895 forms biofilms and invades epithelial cells. Tn5 mutagenesis identified a mutation responsible for both phenotypes.
Haiqing Sheng +4 more
doaj +2 more sources
Structural analysis and architectural principles of the bacterial amyloid curli [PDF]
Nature Communications, 2023 Two decades have passed since the initial proposition that amyloids are not only (toxic) byproducts of an unintended aggregation cascade, but that they can also be produced by an organism to serve a defined biological function.
Mike Sleutel +3 more
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Expression of curli by Escherichia coli O157:H7 strains isolated from patients during outbreaks is different from similar strains isolated from leafy green production environments [PDF]
Frontiers in Cellular and Infection Microbiology, 2016 We previously reported that the strains of Escherichia coli O157:H7 (EcO157) that survived longer in austere soil environment lacked expression of curli, a fitness trait linked with intestinal colonization.
Subbarao Venkata Ravva +2 more
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Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9. [PDF]
PLoS Pathogens, 2017 Bacterial biofilms are associated with numerous human infections. The predominant protein expressed in enteric biofilms is the amyloid curli, which forms highly immunogenic complexes with DNA. Infection with curli-expressing bacteria or systemic exposure
Sarah A Tursi +9 more
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Congo Red Interactions with Curli-Producing E. coli and Native Curli Amyloid Fibers. [PDF]
PLoS ONE, 2015 Microorganisms produce functional amyloids that can be examined and manipulated in vivo and in vitro. Escherichia coli assemble extracellular adhesive amyloid fibers termed curli that mediate adhesion and promote biofilm formation.
Courtney Reichhardt +6 more
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The bacterial amyloid curli is associated with urinary source bloodstream infection. [PDF]
PLoS ONE, 2014 Urinary tract infections are the most common cause of E. coli bloodstream infections (BSI) but the mechanism of bloodstream invasion is poorly understood.
Chia Hung +4 more
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Serum Amyloid A3 Fuels a Feed-Forward Inflammatory Response to the Bacterial Amyloid Curli in the Enteric Nervous SystemSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: Mounting evidence suggests the gastrointestinal microbiome is a determinant of peripheral immunity and central neurodegeneration, but the local disease mechanisms remain unknown.
Peter Verstraelen +14 more
doaj +3 more sources
Interspecies Cross-seeding Between Curli Subunits and Curli-dependent Pellicle Biofilm Development by Escherichia coli. [PDF]
, 2013 The Earth’s bacterial population is primarily found in heterogeneous communities called biofilms. Bacteria in biofilms are enclosed in a matrix composed of proteins, DNAs, and polysaccharides.
Zhou, Yizhou
core +5 more sources
Twin Research and Human Genetics, 2020 AbstractThis letter reflects on my collaborations with Nick Martin over the past 18 years. Working together we have applied twin-family and statistical genetics methods to examine the genetic architecture and identify genetic variants influencing a range of physical, psychological and social traits.
openaire +5 more sources