Results 1 to 10 of about 4,544,497 (292)

Synergistic Inhibition of Protein Fibrillation by Proline and Sorbitol: Biophysical Investigations. [PDF]

PLoS ONE, 2016
We report here interesting synergistic effects of proline and sorbitol, two well-known chemical chaperones, in the inhibition of fibrillation of two proteins, insulin and lysozyme.
Sinjan Choudhary, Shreyada N Save, Nand Kishore, Ramakrishna V Hosur   +3 more
doaj   +8 more sources

Proxied therapeutic inhibition on sclerostin and atrial fibrillation risk [PDF]

Communications Medicine
Background Pharmacological inhibition of sclerostin (SOST) is clinically applied to treat osteoporosis. However, large-scale randomized controlled trials have reported conflicting findings regarding the cardiovascular effects of SOST inhibition.
Yu Qian, Peng-Lin Guan, Jingyan Hu, Ming-Yu Han, Yi-Hu Fang, Wei-Lin Wang, Saber Khederzadeh, Yun-Piao Hou, Mo-Chang Qiu, Jian-Hua Gao, Cheng-Da Yuan, Fei Huang, David Karasik, Ching-Lung Cheung, Liu Yang, Yong Wang, Chao Zheng, Lin Bo, Hou-Feng Zheng   +18 more
doaj   +2 more sources

Absence of arrhythmogenic effects in cAMP subcellular compartments supports PDE8 as a target in atrial fibrillation [PDF]

Journal of Molecular and Cellular Cardiology Plus
Background: Targeting Phosphodiesterase 8B (PDE8B) has been proposed as a strategy to restore L-type Ca 2+ current (I Ca,L ) in patients with atrial fibrillation (AF).
David Revuelta, Nefeli Grammatika Pavlidou, Cristina Aceituno, Issam Abu Taha, Andrea Brunetti, Antonino Ginel, Evaldas Girdauskas, Dobromir Dobrev, Leif Hove-Madsen, Cristina E. Molina   +9 more
doaj   +2 more sources

Role of Anion Identity in the Assembly and Morphology of Whey Protein Isolate Nanofibril Aggregates [PDF]

Foods
To investigate the respective contributions of cations (Na+, K+, Zn2+, Fe3+) and anions (Cl− and SO42−) to the formation of whey protein isolate (WPI)-based nanofibrils, eight salts with a 4 × 2 factorial design were added to WPI solutions.
Shirong Dong, Wei Xu, Yu Sun, Yuju Yang, Chun Bian, Qi Han   +5 more
doaj   +2 more sources

Macrophage migration inhibitory factor in atrial fibrillation [PDF]

Frontiers in Immunology
Macrophage migration inhibitory factor (MIF) is a multifunctional upstream cytokine that has attracted increasing attention for its role in the initiation and perpetuation of atrial fibrillation (AF).
Xize Wu, Shan Gao, Ruiying Wang, Qicheng Cai, Minglin Ruan, Jiaqi Ren, Yuxi Huang, Yue Li, Lihong Gong   +8 more
doaj   +2 more sources

Apomorphine Targets the Pleiotropic Bacterial Regulator Hfq

Antibiotics, 2021
Hfq is a bacterial regulator with key roles in gene expression. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, thanks to its binding to small regulatory noncoding RNAs. This property is of primary importance
Florian Turbant, David Partouche, Omar El Hamoui, Sylvain Trépout, Théa Legoubey, Frank Wien, Véronique Arluison   +6 more
doaj   +1 more source

Unraveling the Interaction of a Neurological Drug Rivastigmine with Human Insulin Protein: A Biophysical Method in Combination with Molecular Docking and Molecular Dynamics Simulation

Journal of Disability Research, 2023
The study aims to examine the aggregation of proteins due to their association with various conformational problems including well-known neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.
Nada H. Aljarba, Reem A. Alqahtani, Saad Alkahtani, Mehvash Zaki   +3 more
doaj   +1 more source

Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition

Molecules, 2022
Most neurodegenerative diseases such as Alzheimer’s disease, type 2 diabetes, Parkinson’s disease, etc. are caused by inclusions and plaques containing misfolded protein aggregates.
Sushma Subedi, Santanu Sasidharan, Niharika Nag, Prakash Saudagar, Timir Tripathi   +4 more
doaj   +1 more source

Decelerate amyloid fibrillation by the alkaloids extracted from Stephania venosa

Journal of Associated Medical Sciences, 2023
Background: Naturally occurring phytochemical compounds have received considerable attention as alternative candidates for anti-amyloidogenic agents. Objectives: This study, utilizing human insulin and amyloid-β peptide as an in vitro model, determined ...
Krai Daowtak, Wilart Pompimon, Milena Salerno, Chatchanok Udomtanakunchai   +3 more
doaj   +1 more source

Aggregation of an Amyloidogenic Peptide on Gold Surfaces

Biomolecules, 2023
Solid surfaces have been shown to affect the aggregation and assembly of many biomolecular systems. One important example is the formation of protein fibrils, which can occur on a range of biological and synthetic surfaces.
David L. Cheung
doaj   +1 more source