The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation [PDF]
, 2005 Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal ...
Ravens, U. +7 more
core +1 more source
Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Pathogens, 2013 Misfolding and aggregation into amyloids of the prion protein (PrP) is responsible for the development of fatal transmissible neurodegenerative diseases.
Raymond Chung +4 more
doaj +1 more source
Frontiers in Physiology, 2020 Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation.
Laia Pazó-Sayós +3 more
doaj +1 more source
Protein Disulfide Isomerase Interacts with Tau Protein and Inhibits Its Fibrillization
PLoS ONE, 2013 Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thought to be related to neuronal toxicity. Physiological inhibitors of Tau fibrillization hold promise for developing new strategies for treatment of Alzheimer disease.
Li-Rong Xu +3 more
openaire +4 more sources
Nucleation of protein fibrillation by nanoparticles. [PDF]
, 2007 Nanoparticles present enormous surface areas and are found to enhance the rate of protein fibrillation by decreasing the lag time for nucleation. Protein fibrillation is involved in many human diseases, including Alzheimer's, Creutzfeld-Jacob disease ...
Xue, Wei-Feng +14 more
core +1 more source
Heterologous Stacking of Prion Protein Peptides Reveals Structural Details of Fibrils and Facilitates Complete Inhibition of Fibril Growth [PDF]
Journal of Biological Chemistry, 2009 Fibrils play an important role in the pathogenesis of amyloidosis; however, the underlying mechanisms of the growth process and the structural details of fibrils are poorly understood. Crucial in the fibril formation of prion proteins is the stacking of PrP monomers.
Ronald S, Boshuizen +5 more
openaire +2 more sources
Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? [PDF]
, 2009 Chronic heart failure increases the risk of atrial fibrillation (AF), with the prevalence of AF paralleling the severity of heart failure.1 Factors that underlie this increased susceptibility to AF may include electrical, structural, and neurohumoral ...
Rankin, A.C., Workman, A.J.
core +1 more source
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Estes, M. K. +4 more
core +3 more sources
Biomimetics, 2023 Surface engineering of nanoparticles has been widely used in biosensing and assays, where sensitivity was mainly limited by plasmonic colour change or electrochemical responses.
Changxin Wang +4 more
doaj +1 more source
RSC Advances, 2022 Epicatechin gallate prevents structural transformations in m-OLF and thus inhibits its aggregation into amyloid fibrils.
Ritika Sharma +3 more
openaire +2 more sources