Results 41 to 50 of about 4,544,497 (292)

Mechanisms of termination and prevention of atrial fibrillation by drug therapy [PDF]

, 2011
Atrial fibrillation (AF) is a disorder of the rhythm of electrical activation of the cardiac atria. It is the most common cardiac arrhythmia, has multiple aetiologies, and increases the risk of death from stroke.
Smith, G.L., A.J. Workman, Rankin, A.C., A.C. Rankin, Workman, A.J., G.L. Smith   +5 more
core   +1 more source

Understanding Inhibition of Protein Amyloid Fibril Formation

, 2023
Dažniausiai pasitaikantys neurodegeneraciniai sutrikimai yra Alzheimerio ir Parkinsono ligos. Nepaisant skirtumų tarp kognityvinių simptomų, pasireiškimo vietos organizme, bei progresavimo greičio, šių ligų patologiniai požymiai yra panašūs ir siejami su baltymų agregacija į netirpius ir neuronams toksiškus darinius.
openaire   +2 more sources

Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

Biomolecules, 2019
Self-assembly of proteins to β-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress ...
Zahra Najarzadeh, Hossein Mohammad-Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Thorbjørn Vincent Sønderby, Seyed Abbas Shojaosadati, Dina Morshedi, Kristian Strømgaard, Georg Meisl, Duncan Sutherland, Jan Skov Pedersen, Daniel E. Otzen   +11 more
doaj   +1 more source

Effects of triphala and guggul aqueous extracts on inhibition of protein fibrillation and dissolution of preformed fibrils

RSC Advances, 2017
Herbal preparations such as triphala and guggul aqueous extracts have ability to inhibit protein fibrillation which is known to be an important process responsible for many neurodegenerative and other diseases.
S. N. Save, S. Choudhary
openaire   +2 more sources

Electrophysiological and arrhythmogenic effects of 5-hydroxytryptamine on human atrial cells are reduced in atrial fibrillation [PDF]

, 2007
5-Hydroxytryptamine (5-HT) is proarrhythmic in atrial cells from patients in sinus rhythm (SR) via activation of 5-HT₄ receptors, but its effects in atrial cells from patients with atrial fibrillation (AF) are unknown.
Kane, K.A., Rankin, A.C., Workman, A.J., Pau, D.   +3 more
core   +1 more source

Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial‐mesenchymal transition and inflammatory response

Physiological Reports, 2022
Chronic kidney disease (CKD) is an increasing and life‐threatening disease worldwide. Recent evidence indicates that blood coagulation factors promote renal dysfunction in CKD patients.
Lixin Fang, Koji Ohashi, Hayato Ogawa, Naoya Otaka, Hiroshi Kawanishi, Tomonobu Takikawa, Yuta Ozaki, Kunihiko Takahara, Minako Tatsumi, Mikito Takefuji, Toyoaki Murohara, Noriyuki Ouchi   +11 more
doaj   +1 more source

Inhibition of the formation of amyloid β‐protein fibrils using biocompatible nanogels as artificial chaperones [PDF]

FEBS Letters, 2006
The formation of fibrils by amyloid β‐protein (Aβ) is considered as a key step in the pathology of Alzheimer's disease (AD). Inhibiting the aggregation of Aβ is a promising approach for AD therapy. In this study, we used biocompatible nanogels composed of a polysaccharide pullulan backbone with hydrophobic cholesterol moieties (cholesterol‐bearing ...
Ikeda, Keisuke, Okada, Takuma, Sawada, Shin-ichi, Akiyoshi, Kazunari, Matsuzaki, Katsumi   +4 more
openaire   +2 more sources

Amyloid Fibrils of Pisum sativum L. Vicilin Inhibit Pathological Aggregation of Mammalian Proteins

International Journal of Molecular Sciences, 2023
Although incurable pathologies associated with the formation of highly ordered fibrillar protein aggregates called amyloids have been known for about two centuries, functional roles of amyloids have been studied for only two decades. Recently, we identified functional amyloids in plants. These amyloids formed using garden pea Pisum sativum L.
Maksim I. Sulatsky, Mikhail V. Belousov, Anastasiia O. Kosolapova, Ekaterina V. Mikhailova, Maria N. Romanenko, Kirill S. Antonets, Irina M. Kuznetsova, Konstantin K. Turoverov, Anton A. Nizhnikov, Anna I. Sulatskaya   +9 more
openaire   +2 more sources

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Exploring serum and glucocorticoid-regulated kinase 1: A promising target for COVID-19 and atrial fibrillation treatment

Heart Rhythm O2
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase that is involved in various cellular pathways, such as ion transport, cell survival, proliferation, and immune responses.
Jamal E-Fatima, PhD, Faez Iqbal Khan, PhD, Dakun Lai, PhD   +2 more
doaj   +1 more source