Results 51 to 60 of about 4,544,497 (292)

Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase. [PDF]

PLoS ONE, 2016
Selective inhibitors of factor Xa (FXa) are widely recognized as useful therapeutic tools for stroke prevention in non-valvular atrial fibrillation or venous thrombosis.
Masanori Tsujimoto, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Yuko Kito, Yukiko Enomoto, Hiroki Iida, Shinji Ogura, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Toru Iwama   +10 more
doaj   +1 more source

Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling

Cells, 2021
Both, the decreased L-type Ca2+ current (ICa,L) density and increased spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation (AF).
Franziska Reinhardt, Kira Beneke, Nefeli Grammatica Pavlidou, Lenard Conradi, Hermann Reichenspurner, Leif Hove-Madsen, Cristina E. Molina   +6 more
doaj   +1 more source

The engineered peptide construct NCAM1-Aβ inhibits fibrillization of the human prion protein (PrP)

Acta Biochimica Polonica, 2022
In prion diseases, the prion protein (PrP) becomes misfolded and forms fibrillar aggregates that are responsible for prion infectivity and pathology. So far, no drug or treatment procedures have been approved for prion disease treatment. We have previously shown that engineered cell-penetrating peptide constructs can reduce the amount of prion ...
Maciej, Gielnik, Lilia, Zhukova, Igor, Zhukov, Astrid, Gräslund, Maciej, Kozak, Sebastian, Wärmländer   +5 more
openaire   +3 more sources

Oral Bisphosphonates and Risk of Atrial Fibrillation and Flutter in Women: A Self-Controlled Case-Series Safety Analysis [PDF]

, 2009
Background: A recent trial unexpectedly reported that atrial fibrillation, when defined as serious, occurred more often in participants randomized to an annual infusion of the relatively new parenteral bisphosphonate, zoledronic acid, than among those ...
Aroon Hingorani, Douglas, I, Hingorani, A, Douglas, Ian, MacAllister, Raymond, Grosso, Anthony, MacAllister, R, Anthony Grosso, Liam Smeeth, Smeeth, Liam, Raymond MacAllister, Grosso, A, Smeeth, L, Ian Douglas, Hingorani, Aroon   +14 more
core   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly [PDF]

Journal of Biological Chemistry, 2010
Accumulation of amyloid β-protein (Aβ) into brain parenchymal plaques and the cerebral vasculature is a pathological feature of Alzheimer disease and related disorders. Aβ peptides readily form β-sheet-containing oligomers and fibrils. Previously, we reported a strong interaction between myelin basic protein (MBP) and Aβ peptides that resulted in ...
Mei-Chen, Liao, Michael D, Hoos, Darryl, Aucoin, Mahiuddin, Ahmed, Judianne, Davis, Steven O, Smith, William E, Van Nostrand   +6 more
openaire   +2 more sources

Human lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis

Amyloid, 2023
Systemic AA amyloidosis is a world-wide occurring protein misfolding disease in humans and animals that arises from the formation of amyloid fibrils from serum amyloid A (SAA) protein and their deposition in multiple organs. To identify new agents that prevent fibril formation from SAA protein and to determine their mode of action. We used a cell model
Tim, Moderer, Ioana, Puşcalău-Gîrţu, Christian, Haupt, Julian, Baur, Armando, Rodríguez-Alfonso, Sebastian, Wiese, Christoph Q, Schmidt, Miroslav, Malešević, Wolf-Georg, Forssmann, Ludger, Ständker, Marcus, Fändrich   +10 more
openaire   +2 more sources

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria.

PLoS ONE, 2013
The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal models ...
Saori Morota, Theodor Manolopoulos, Atli Eyjolfsson, Per-Ola Kimblad, Per Wierup, Carsten Metzsch, Sten Blomquist, Magnus J Hansson   +7 more
doaj   +1 more source

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Frontiers in Cell and Developmental Biology, 2021
The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and survival of B-lineage cells and, hence, represents a suitable drug target.
H. Yesid Estupiñán, H. Yesid Estupiñán, Anna Berglöf, Rula Zain, Rula Zain, C. I. Edvard Smith   +5 more
doaj   +1 more source