Results 71 to 80 of about 4,544,497 (292)

Molecular Mechanisms Underlying the Flavonoid-Induced Inhibition of α-Synuclein Fibrillation

, 2009
The molecular mechanism underlying the flavonoid-induced inhibition of α-synuclein fibrillation was thoroughly examined by various biochemical and biophysical approaches.
Fink, Anthony L., Uversky, Vladimir N., Munishkina, Larissa A., Meng, Xiaoyun, Anthony L. Fink (2353009), Larissa A. Munishkina (2353006), Xiaoyun Meng (2353012), Vladimir N. Uversky (123421), Anthony L. Fink, Vladimir N. Uversky, Larissa A. Munishkina, Xiaoyun Meng   +11 more
core   +2 more sources

Thrombin generation by calibrated automated thrombography in goat plasma: Optimization of an assay

Research and Practice in Thrombosis and Haemostasis, 2021
The goat model of atrial fibrillation (AF) allows investigation of the effect of AF on coagulation. However, assays for goat plasma are not available from commercial sources.
Elisa D'Alessandro, Billy Scaf, René vanOerle, Frans A. vanNieuwenhoven, Arne vanHunnik, Sander Verheule, Ulrich Schotten, Hugo ten Cate, Henri M. H. Spronk   +8 more
doaj   +1 more source

Catheter ablation of atrial fibrillation : radiofrequency catheter ablation for redo procedures after cryoablation [PDF]

, 2013
Aim: To evaluate the effectiveness of two different strategies using radiofrequency catheter ablation for redo procedures after cryoablation of atrial fibrillation. Methods: Thirty patients (paroxysmal atrial fibrillation: 22 patients, persistent atrial
Gramley, Felix, Kettering, Klaus
core   +1 more source

Zinc Fingers as Programmable Metalloprotein Scaffolds for Altering Pathogenic Biomolecular Phase Transitions

Advanced Science, EarlyView.
Modular zinc finger (ZF) metalloproteins function as programmable biomolecular scaffolds that modulate pathogenic amyloid assembly. Through direct protein–protein interactions, ZF arrays alter amyloid phase behavior and redirect β‐sheet fibrillization toward nontoxic aggregates.
Seongmin Park, Yunha Hwang, Jimin Kwak, Yuxi Lin, Hye‐Yeon Park, Eunju Nam, Jiyeon Han, Soyeon Park, Hyunyong Kim, Ju‐Eun Kim, Hyun Goo Kang, Jiyong Park, Young‐Ho Lee, Kyoung‐Shim Kim, Chul‐Ho Lee, Seung Jae Lee, Mi Hee Lim   +16 more
wiley   +1 more source

Atrial fibrillation and its arrhythmogenesis associated with insulin resistance

Cardiovascular Diabetology, 2019
Background Insulin resistance (IR) is considered as a risk factor for atrial fibrillation (AF) even before diabetes develops. The pathophysiology and underlying mechanism are largely unclear.
Yi-Hsin Chan, Gwo-Jyh Chang, Ying-Ju Lai, Wei-Jan Chen, Shang-Hung Chang, Li-Man Hung, Chi-Tai Kuo, Yung-Hsin Yeh   +7 more
doaj   +1 more source

Protective effect of surfactant inhalation against warm ischemic injury in an isolated rat lung ventilation model. [PDF]

PLoS ONE, 2013
Warm ischemia-reperfusion injury remains a crucial issue in transplantation following the cardiac death of donors. Previously, we showed that surfactant inhalation during warm ischemia mitigated ischemia-reperfusion injury.
Akihiro Ohsumi, Fengshi Chen, Jin Sakamoto, Daisuke Nakajima, Masashi Kobayashi, Toru Bando, Hiroshi Date   +6 more
doaj   +1 more source

Bacteria‐Derived 1‐Allylpiperazine Alleviates Symptoms of Parkinson's Disease Model by Promoting Autophagy

Advanced Science, EarlyView.
Parkinson's disease currently has no disease‐modifying therapies. In Caenorhabditis elegans, Escherichia coli E8 alleviates α‐synuclein‐provoked PD‐related defects through its bioactive metabolite 1‐ALPP, which combats PD by triggering AMPK/mTOR/HLH‐30‐dependent autophagy and suppressing α‐synuclein LLPS‐mediated fibrillization.
Mingqin Qu, Xinyuan Zhang, Xinyi Chen, Jiaxin Shi, Meng Xu, Fuhao Wang, Jinling Lv, Jiaman Sun, Weiyi Niu, Zihan Liu, Li Li, Fufeng Liu, Xiangming Wang   +12 more
wiley   +1 more source

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
Neurodegenerative protein misfolding diseases, including prionopathies, share the common feature of accumulating specific misfolded proteins, with a molecular mechanism closely related. Misfolded prion protein (PrP) generates soluble oligomers that, in turn, aggregate into amyloid fibers. Preventing the formation of these entities, crucially associated
Cavaliere, Paola, Torrent, Joan, Prigent, Stephanie, Granata, Vincenzo, Pauwels, Kris, Pastore, Annalisa, Rezaei, Human, Zagari, Adriana   +7 more
openaire   +3 more sources

Human Engineered Heart Tissues Reproduce Trigger‐ and Substrate‐Driven Mechanisms of Ventricular Tachycardia

Advanced Science, EarlyView.
Engineered heart tissues (EHTs) derived from human iPSCs replicate mechanisms of ventricular tachycardia at the tissue level. Acquired Long‐QT conditions cause early afterdepolarizations, wavebreak, and transient rotors; in contrast, focal cryoinjury forms a stable substrate that supports ongoing reentry.
Matthew Fiedler, Alejandra Vasquez Limeta, Ernesto Reyes Sanchez, Leah Carter, Francisco Altamirano   +4 more
wiley   +1 more source

Plant-Based Inhibitors of Protein Aggregation

Biomolecules
The assembly of amyloidogenic proteins and peptides into toxic oligomeric and fibrillar aggregates is closely connected to the onset and progression of more than 50 protein diseases, such as Alzheimer’s disease, Parkinson’s disease, prion disease, and ...
Olha Zhytniakivska, Tanmay Chaturvedi, Mette Hedegaard Thomsen   +2 more
doaj   +1 more source