Results 81 to 90 of about 4,544,497 (292)

Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid β protein

Neuroscience Letters, 2008
Fisetin (3,3',4',7-tetrahydroxyflavone) has been found to be neuroprotective, induce neuronal differentiation, enhance memory, and inhibit the aggregation of the amyloid beta protein (Abeta) that may cause the progressive neuronal loss in Alzheimer's disease.
Tatsuhiro, Akaishi, Takeo, Morimoto, Mami, Shibao, Sayaka, Watanabe, Kumiko, Sakai-Kato, Naoko, Utsunomiya-Tate, Kazuho, Abe   +6 more
openaire   +3 more sources

N-terminal arginines modulate plasma-membrane localization of Kv7.1/KCNE1 channel complexes [PDF]

, 2011
Background and Objective: The slow delayed rectifier current (IKs) is important for cardiac action potential termination. The underlying channel is composed of Kv7.1 α-subunits and KCNE1 β-subunits.
Takac, Ina, Ehrlich, Joachim, Zenawit Girmatsion, Biliczki, Peter, Biliczki Peter, Stefan H Hohnloser, Stefan H. Hohnloser, Schwerthelm Christin, Hohnloser, Stefan H., Christin Schwerthelm, Girmatsion, Zenawit, Joachim R. Ehrlich, Hohnloser Stefan H., Ina Takac, Takac Ina, Peter Biliczki, Ehrlich Joachim R., Girmatsion Zenawit, Schwerthelm, Christin, Joachim R Ehrlich   +19 more
core   +2 more sources

Stroke‐Heart Syndrome: Mechanisms, Temporal Phenotypes, and Diagnostic Reasoning

Advanced Science, EarlyView.
Stroke‐heart syndrome describes new or worsened cardiac abnormalities after acute stroke. This Review defines its clinical boundaries, traces autonomic, inflammatory, endothelial, and supply‐demand mechanisms across time, and proposes provisional phenotypes that integrate lesion location, premorbid cardiac substrate, serial biomarkers ...
Fa Lin, Jian Lyu, Yanci Liu, Zhiyuan Feng, Jie Bao, Wenxiong Song, Bingcheng Zhu, Minghao Liu, Jionghao Xue, Jiadi Weng, Jiani Zhang, Jizong Zhao, Xiaolin Chen, Bin Dong   +13 more
wiley   +1 more source

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

Frontiers in Pharmacology, 2019
α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of both sporadic and familial forms of Parkinson's disease (PD). These
Hayate Javed, Mohamed Fizur Nagoor Meeran, Sheikh Azimullah, Abdu Adem, Bassem Sadek, Shreesh Kumar Ojha   +5 more
doaj   +1 more source

β2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes [PDF]

Journal of Biological Chemistry, 2014
Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), a substrate commonly used to measure cell viability, to a ...
T. Jakhria, A. L. Hellewell, M. Y. Porter, M. P. Jackson, K. W. Tipping, W.-F. Xue, S. E. Radford, E. W. Hewitt   +7 more
openaire   +3 more sources

Effect of selective IK,ACh inhibition by XAF-1407 in an equine model of tachypacing-induced persistent atrial fibrillation

, 2020
Background and Purpose: Inhibition of the G-protein gated ACh-activated inward rectifier potassium current, IK,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF).
Tang, Raymond, Raymond Tang, Scott Lunddahl, Christine, Jespersen, Thomas, Jackson, Claire, Ulrich Schotten, Thomas Jespersen, Sather, Stefan Michael, Sorensen, Ulrik Svane, Ford, John, Lunddahl, Christine Scott, Ulrik Svane Sørensen, Dalgas Nissen, Sarah, Loft-Andersen, Ameli Victoria, Pyotr Platonov, Maja Adler Hess Jensen, Carstensen, Helena, Svane Sørensen, Ulrik, Adler Hess Jensen, Maja, Schotten, Ulrich, Hesselkilde, Eva Melis, Said El‐Haou, Kirby, Robert, Melis Hesselkilde, Eva, Stefan Michael Sattler, Milnes, James, Fenner, Merle Friederike, Sarah Dalgas Nissen, El-Haou, Said, Nissen, Sarah Dalgas, Rikke Buhl, Christine Scott Lunddahl, Helena Carstensen, Merle Friederike Fenner, Jensen, Maja Adler Hess, Sattler, Stefan Michael, Ameli Victoria Loft‐Andersen, Claire Jackson, Buhl, Rikke, Platonov, Pyotr, Eva Melis Hesselkilde, John Ford, James Milnes, Robert Kirby   +43 more
core   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils

eLife, 2019
Removing or preventing the formation of α -synuclein aggregates is a plausible strategy against Parkinson’s disease. To this end, we have engineered the β -wrapin ...
Emil D. Agerschou, Theodora Saridaki, Patrick Flagmeier, Céline Galvagnion, Daniel Komnig, Akansha Nagpal, Natalie Gasterich, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Aaron Voigt, Dieter Willbold, Christopher M. Dobson, Björn H. Falkenburger, Wolfgang Hoyer, Alexander K. Buell   +15 more
openaire   +7 more sources

Hydropathy: the controlling factor behind the inhibition of Aβ fibrillation by graphene oxide

, 2016
Protein and peptide aggregation/fibrillation is reported to be responsible for several neurological disorders. Fibrillation of the amyloid β-peptide fragment (25–35) which is a biologically active region of the full length peptide, has been observed to ...
DasGupta, Sunando, Bag, Sudipta, Dasgupta, Swagata, Sett, Ayantika   +3 more
core   +1 more source

Inhibition of Mitogen-Activated Protein Kinase Erk1/2 Promotes Protein Degradation of ATP Binding Cassette Transporters A1 and G1 in CHO and in HuH7 cells. [PDF]

, 2013
Signal transduction modulates expression and activity of cholesterol transporters. We recently demonstrated that the Ras/mitogen-activated protein kinase (MAPK) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through ...
Enrich Bastús, Carles, Enrich Carlos, Karen Cecilia Chan, Monira Hoque, Darabi, Masoud, Reverter Martín, Meritxell, Hoque, Monira, Rentero Alfonso, Carles, Meritxell Reverter, Rentero Carles, Melanie Manetsch, Masoud Darabi, Mulay, Vishwaroop, Peta Wood, Grewal Thomas, Álvarez-Guaita, Anna, Heeren, Joerg, Anna Alvarez-Guaita, Kerry-Anne Rye, Darabi Masoud, Rye Kerry-Anne, Chan, Karen Cecilia, Manetsch, Melanie, Mulay Vishwaroop, Manetsch Melanie, Heeren Joerg, Carlos Enrich, Cairns, Rose, Reverter Meritxell, Joerg Heeren, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood Peta, Wood, Peta, Grewal, Thomas, Rye, Kerry-Anne, Chan Karen Cecilia, Álvarez-Guaita Anna, Thomas Grewal, Hoque Monira, Cairns Rose   +41 more
core   +2 more sources