Results 21 to 30 of about 4,544,497 (292)

XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation [PDF]

, 2014
A John Camm,1 Pierre Amarenco,2 Sylvia Haas,3 Susanne Hess,4 Paulus Kirchhof,5,6 Martin van Eickels,4 Alexander GG Turpie71Division of Clinical Sciences, St George's, University of London, London, UK; 2Department of Neurology and Stroke Center, Paris-
Hess, S, Camm, AJ, Amarenco, Pierre, Eickels MV, Turpie, AG, Hess, Susanne, Haas, S, Turpie, Alexander G G, Kirchhof, P, van Eickels, M, Haas, Sylvia, Kirchhof, Paulus; id_orcid, Amarenco, P, Camm AJ, Hess S, Camm, John, Amarenco P, Van Eickels, Martin, Turpie AGG, Kirchhof P, Haas S   +20 more
core   +1 more source

Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival

Pathogens, 2018
Hfq is a pleiotropic regulator that has key roles in the control of genetic expression. The protein noticeably regulates translation efficiency and RNA decay in Gram-negative bacteria, due to the Hfq-mediated interaction between small regulatory ...
David Partouche, Florian Turbant, Omar El Hamoui, Camille Campidelli, Marianne Bombled, Sylvain Trépout, Frank Wien, Véronique Arluison   +7 more
doaj   +1 more source

Insights into a Protein-Nanoparticle System by Paramagnetic Perturbation NMR Spectroscopy

Molecules, 2020
Background: The interaction between proteins and nanoparticles is a very relevant subject because of the potential applications in medicine and material science in general.
Yamanappa Hunashal, Cristina Cantarutti, Sofia Giorgetti, Loredana Marchese, Federico Fogolari, Gennaro Esposito   +5 more
doaj   +1 more source

Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity [PDF]

Journal of Biological Chemistry, 2012
The pathogenesis of Alzheimer disease appears to be strongly linked to the aggregation of amyloid-β (Aβ) peptide and, especially, formation of soluble Aβ1-42 oligomers. It was recently demonstrated that the cellular prion protein, PrP(C), binds with high affinity to these oligomers, acting as a putative receptor that mediates at least some of their ...
Krzysztof, Nieznanski, Jin-Kyu, Choi, Shugui, Chen, Krystyna, Surewicz, Witold K, Surewicz   +4 more
openaire   +2 more sources

Systematic Analysis of Gene Expression Differences between Left and Right Atria in Different Mouse Strains and in Human Atrial Tissue [PDF]

, 2011
Background: Normal development of the atria requires left-right differentiation during embryonic development. Reduced expression of Pitx2c (paired-like homeodomain transcription factor 2, isoform c), a key regulator of left-right asymmetry, has recently ...
Fabritz Larissa, Brown Nigel A., Hoffmeier Andreas, Hans Schöler, Piccini, Ilaria, Brown, NA, Scheld, Hans H, Greber, B, Kahr, Peter C, Piccini Ilaria, Boris Greber, Greber Boris, Schöler, H, Hans H. Scheld, Ilaria Piccini, Nigel A Brown, Kahr Peter C., Kahr, PC, Fabritz, Larissa; id_orcid, Hans H Scheld, Piccini, I, Schöler Hans, Kirchhof Paulus, Peter C. Kahr, Brown, Nigel A, Scheld, HH, Kirchhof, P, Fabritz, L, Kirchhof, Paulus; id_orcid, Paulus Kirchhof, Schöler, Hans, Scheld Hans H., Greber, Boris, Hoffmeier, A, Peter C Kahr, Larissa Fabritz, Nigel A. Brown, Andreas Hoffmeier, Hoffmeier, Andreas   +38 more
core   +1 more source

Ananas comosus (L.) Merr. extract inhibits protein glycation and protein fibrillation through in vitro and in silico methods [PDF]

Herba Polonica
Introduction: Evidence from traditional medicine proved that plant-based natural products could provide a significant opportunity for the development of therapeutic agents against pathological peptide fibril formation.
BABATUNDE OSO, IGE OLAOYE, ADEPEJU ABERUAGBA   +2 more
doaj   +1 more source

Aminoquinolones and Their Benzoquinone Dimer Hybrids as Modulators of Prion Protein Conversion

Molecules, 2022
Prion Diseases or Transmissible Spongiform Encephalopathies are neurodegenerative conditions associated with a long incubation period and progressive clinical evolution, leading to death.
Amanda Rodrigues Pinto Costa, Marcelly Muxfeldt, Fernanda da Costa Santos Boechat, Maria Cecília Bastos Vieira de Souza, Jerson Lima Silva, Marcela Cristina de Moraes, Luciana Pereira Rangel, Tuane Cristine Ramos Gonçalves Vieira, Pedro Netto Batalha   +8 more
doaj   +1 more source

The role of inhibitory G proteins and regulators of G protein signalling in the in-vivo control of heart rate and predisposition to cardiac arrhythmias [PDF]

, 2012
Inhibitory heterotrimeric G-proteins and the control of heart rate.The activation of cell signalling pathways involving inhibitory heterotrimeric G-proteins acts to slow the heart rate via modulation of ion channels.
Aaisha Opel, Aaisha eOpel, Richard Ang, Richard eAng, Opel, A, Tinker, A, Andrew Tinker, Ang, R, Andrew eTinker   +8 more
core   +1 more source

Enhanced cardiomyocyte reactive oxygen species signaling promotes ibrutinib-induced atrial fibrillation

Redox Biology, 2020
Atrial fibrillation (AF) occurs in up to 11% of cancer patients treated with ibrutinib. The pathophysiology of ibrutinib promoted AF is complicated, as there are multiple interactions involved; the detailed molecular mechanisms underlying this are still ...
Xinyu Yang, Na An, Changming Zhong, Manke Guan, Yuchen Jiang, Xinye Li, Hanlai Zhang, Liqin Wang, Yanfei Ruan, Yonghong Gao, Nian Liu, Hongcai Shang, Yanwei Xing   +12 more
doaj   +1 more source

AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts. [PDF]

PLoS ONE, 2014
Atrial hypertrophy and fibrosis are essential pathological features of atrial fibrillation. Recently, adiponectin has become a protein of interest due to its beneficial effects on cardiovascular diseases.
Tengwei Cao, Zhen Gao, Lingyun Gu, Minglong Chen, Bing Yang, Kejiang Cao, He Huang, Mingfang Li   +7 more
doaj   +1 more source