Results 11 to 20 of about 4,544,497 (292)

Protein Fibrillation Lag Times During Kinetic Inhibition [PDF]

Biophysical Journal, 2014
Protein aggregation is linked to more than 30 human pathologies, including Alzheimer's and Parkinson's diseases. Since small oligomers that form at the beginning of the fibrillation process probably are the most toxic elements, therapeutic strategies involving fibril fragmentation could be detrimental. An alternative approach, named kinetic inhibition,
Pagano, Rodrigo Sebastián, López Medus, Máximo, Gomez, Gabriela Elena, Couto, Paula Monserrat, Labanda, María Soledad, Landolfo, Lucas, D'Alessio, Cecilia, Caramelo, Julio Javier   +7 more
openaire   +5 more sources

Altered excitation-contraction coupling in human chronic atrial fibrillation [PDF]

, 2012
This review focuses on the (mal)adaptive processes in atrial excitation-contraction coupling occurring in patients with chronic atrial fibrillation. Cellular remodeling includes shortening of the atrial action potential duration and effective refractory ...
Grandi, E., Pandit, S.V., Workman, A.J.
core   +7 more sources

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII-δ. [PDF]

Adv Sci (Weinh)
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Bi HL, Gu YH, Ren KW, Yu XH, Xia YL, Yang XL, Li HH.   +6 more
europepmc   +2 more sources

Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins [PDF]

Prion, 2010
Several neurodegenerative diseases involve the selective damage of neuron cells resulting from the accumulation of amyloid fibril formation. Considering that the formation of amyloid fibrils as well as their precursor oligomers is cytotoxic, the agents that prevent the formation of oligomers and/or fibrils might allow the development of a novel ...
Jihoon, Kim, Masaki, Kobayashi, Makoto, Fukuda, Daisuke, Ogasawara, Natsuki, Kobayashi, Sungwoong, Han, Chikashi, Nakamura, Masaki, Inada, Chisato, Miyaura, Kazunori, Ikebukuro, Koji, Sode   +10 more
openaire   +2 more sources

Inhibiting transthyretin amyloid fibril formation via protein stabilization [PDF]

Proceedings of the National Academy of Sciences, 1996
Transthyretin (TTR) amyloid fibril formation is observed systemically in familial amyloid polyneuropathy and senile systemic amyloidosis and appears to be the causative agent in these diseases. Herein, we demonstrate conclusively that thyroxine (10.8 μM) inhibits TTR fibril formation efficiently in vitro
Miroy, G. J., Lai, Z., Lashuel, H. A., Peterson, S. A., Strang, C., Kelly, J. W.   +5 more
openaire   +3 more sources

Selective inhibition of aggregation/fibrillation of bovine serum albumin by osmolytes: Mechanistic and energetics insights. [PDF]

PLoS ONE, 2017
Bovine serum albumin (BSA) is an important transport protein of the blood and its aggregation/fibrillation would adversely affect its transport ability leading to metabolic disorder.
Moumita Dasgupta, Nand Kishore
doaj   +1 more source

Nontoxic Black Phosphorus Quantum Dots Inhibit Insulin Amyloid Fibrillation at an Ultralow Concentration

iScience, 2020
Summary: Amyloid are protein aggregates formed by cross β structures assemblies. Inhibiting amyloid aggregation or facilitating its disassembly are considered to be two major effective therapeutic strategies in diseases involving peptide or protein ...
Siqi Wang, Chuanxi Li, Yinqiang Xia, Shaohuang Chen, Jordan Robert, Xavier Banquy, Renliang Huang, Wei Qi, Zhimin He, Rongxin Su   +9 more
doaj   +1 more source

RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response. [PDF]

PLoS ONE, 2015
The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness.
Roelien A M Meijering, Marit Wiersma, Denise M S van Marion, Deli Zhang, Femke Hoogstra-Berends, Anne-Jan Dijkhuis, Martina Schmidt, Thomas Wieland, Harm H Kampinga, Robert H Henning, Bianca J J M Brundel   +10 more
doaj   +1 more source

PLXND1-mediated calcium dyshomeostasis impairs endocardial endothelial autophagy in atrial fibrillation

Frontiers in Physiology, 2022
Left atrial appendage (LAA) thrombus detachment resulting in intracranial embolism is a major complication of atrial fibrillation (AF). Endocardial endothelial cell (EEC) injury leads to thrombosis, whereas autophagy protects against EEC dysfunction ...
Mengjia Sun, Mengjia Sun, Zhen Chen, Zhen Chen, Yuanbin Song, Yuanbin Song, Bo Zhang, Bo Zhang, Jie Yang, Jie Yang, Hu Tan, Hu Tan   +11 more
doaj   +1 more source

In Situ Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study

Pathogens, 2019
Hfq is a bacterial protein that regulates gene expression at the post-transcriptional level in Gram-negative bacteria. We have previously shown that Escherichia coli Hfq protein, and more precisely its C-terminal region (CTR), self-assembles into an ...
David Partouche, Valeria Militello, Andrea Gomez-Zavaglia, Frank Wien, Christophe Sandt, Véronique Arluison   +5 more
doaj   +1 more source