Results 231 to 240 of about 11,568 (285)

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Exploring Linalool‐Based Phytotherapy for Excitatory/Inhibitory Imbalance in Alzheimer's Disease: A Review of Lavender and Cannabis Therapeutic Effects on Sleep, Seizures, and Cognition

Phytotherapy Research, EarlyView.
Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli, Giovanni Roviello, Giorgia Magliocca, Emilia Esposito, Anna Pannaccione   +4 more
wiley   +1 more source

From Pathology to Materials Science and Engineering: Harnessing the Amyloid State for Biotechnological Applications. [PDF]

ACS Appl Mater Interfaces
Fallot LB, Natarajan C, Anderson CA, Nagelli EA, Burpo FJ, Limbocker R.   +5 more
europepmc   +1 more source

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

The intrinsically disordered region of the human parathyroid hormone controls functional amyloid properties. [PDF]

J Biol Chem
Sachan S, Bhatia T, Baumann M, Weber M, Gordijenko I, Voigt B, Ott M, Balbach J.   +7 more
europepmc   +1 more source

Expanding the amyloid landscape: structural plasticity of antimicrobial peptides

Landau M, Ragonis-Bachar P, Strati F, Gustavsson E, Khokhlov A, Barnea E, Rayan B, Upcher A.   +7 more
europepmc   +1 more source

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A proteolytic functional amyloid digests pathogenic amyloids

Journal of Materials Chemistry B, 2022
A new triad-based proteolytic functional amyloid (PFA) cleaved Aβ1-40 site-selectively and digested extracellular pathogenic amyloid plaques. Such amyloid-destructors are the first ‘‘amyloid-destroying’’ amyloids.
Tanmay Mondal, Bhubaneswar Mandal
openaire   +2 more sources

Functional amyloid in Pseudomonas [PDF]

Molecular Microbiology, 2010
SummaryAmyloids are highly abundant in many microbial biofilms and may play an important role in their architecture. Nevertheless, little is known of the amyloid proteins. We report the discovery of a novel functional amyloid expressed by a Pseudomonas strain of the P. fluorescens group.
Dueholm, Morten S, Petersen, Steen V, Sønderkær, Mads, Larsen, Poul, Christiansen, Gunna, Hein, Kim L, Enghild, Jan J, Nielsen, Jeppe L, Nielsen, Kåre L, Nielsen, Per H, Otzen, Daniel E   +10 more
openaire   +2 more sources

Functional Amyloids Germinate in Plants

Trends in Plant Science, 2021
First identified in human disorders, amyloids serve biological functions in bacteria, archaea, fungi, and animals; however, their role in plants has remained unexplored. Recently, Antonets et al. identified a functional amyloid in plants, with a crucial role in seed longevity, confirming that amyloids are universally exploited for organisms' adaptation.
Jaime, Santos, Salvador, Ventura
openaire   +2 more sources