Results 181 to 190 of about 3,444,674 (308)

Investigating differences in brain functional networks using hierarchical covariate-adjusted independent component analysis

, 2016
Ran Shi, Ying Guo
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Functional Analysis of Histidine-Dependent Self-Cleaving RNAs Obtained by In Vitro Selection. [PDF]

Chembiochem
Sakimoto N, Tanaka S, Hatakenaka R, Yamaguchi-Miyazaki Y, Tomita-Sudo E, Akita T, Ishigaki T, Iwai S, Kawakami J.   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Systematic enhancer mapping and functional analysis in zebrafish with optimized CRISPR interference. [PDF]

Nucleic Acids Res
Chan J, Wu Z, Liu M, Wang T, Liu H, Cao R, Li X, Li X, Zhan S, Cheng J, Xu Y, He M, Feng Y, Xu Q, Sun Y, Chen L, Hu P.   +16 more
europepmc   +1 more source

Adomian’s decomposition method to modeling power functionally graded thermoelastic materials in heat transfer and thermal stress analysis [PDF]

, 2019
Hamdy M. Youssef, Eman A. N. Al-Lehaibi
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Multi-Omics and Functional Analysis of BFSP1 as a Prognostic and Therapeutic Target in Liver Hepatocellular Carcinoma. [PDF]

Medicina (Kaunas)
Lee KS, Kim J.
europepmc   +1 more source

Functional genetic analysis of the Eucalyptus grandis cellulose synthase 1 (EgCesA1) gene in Arabidopsis thaliana

, 2009
Marja M. Mostert‐O'Neill
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source