Results 211 to 220 of about 7,524,603 (346)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Structural and Functional Analysis of the Human IQSEC2 S1474Qfs*133 Mutation. [PDF]

Biomolecules
Israel Y, Lowenkamp A, Shokhen M, Netser S, Wagner S, Zarowin J, Orth S, Borisov V, Lache O, Levy NS, Levy AP.   +10 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A novel LACC1 variant c.658G>A (p. Asp220Asn) in familial juvenile arthritis: identification and functional analysis. [PDF]

Hum Genomics
Alblooshi H, Mustafa N, Khalam AA, Bharathan A, Mohammed E, Baydoun I, Allam M, Almansoori M, Fatima T, Aljaberi N.   +9 more
europepmc   +1 more source

A functional analysis of the components of the mesencephalic nucleus of the fifth nerve in the cat

, 1972
F.W.J. Cody, R. W. H. Lee, Anthony R. Taylor   +2 more
openalex   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Genome-wide identification and functional analysis of PEL gene family in Brassica napus L. [PDF]

BMC Plant Biol
Xing M, Kang Y, Lv M, Serani BR, Shen Q, Jiao W, Mu W, Chen S, Peng Z, Huang L.   +9 more
europepmc   +1 more source

Deltoid Ligament: Functional Analysis of the Medial Collateral Ligamentous Apparatus of the Ankle Joint [PDF]

, 1983
Ove Rasmussen, C Kromann-Andersen, Svend Boe   +2 more
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Microbial Community and Functional Analysis of Regionally Produced Traditional Korean Grain Vinegar. [PDF]

Microorganisms
Lee SJ, Kim SH, Gwon HM, Park J.
europepmc   +1 more source