Results 231 to 240 of about 33,941,795 (386)

Structural and functional analysis of Escherichia coli membrane disruption by Ib-M peptides. [PDF]

PLoS One
Farfán-García AE, Hernández-Peñaranda IP, Gómez-Duarte OG, Rincón-Barón EJ, Torres-Rodríguez GA, Flórez-Castillo JM.   +5 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Functional analysis of StMAPK19 gene in response to salt stress in potato (Solanum tuberosum L.). [PDF]

BMC Plant Biol
Zhu X, Majeed Y, Duan X, Wang K, Duan H, Luo J, Guan N, Zheng H, Jin H, Chen Z, Li W, Chen S, Tang J, Zhang Y.   +13 more
europepmc   +1 more source

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

Cell, 2016
J. Peters, Alexandre Colavin, Handuo Shi, Tomasz L. Czarny, Matthew H. Larson, Spencer S. Wong, John S. Hawkins, Candy H. S. Lu, B. Koo, E. Marta, A. Shiver, E. Whitehead, J. Weissman, E. Brown, Lei S. Qi, K. C. Huang, C. Gross   +16 more
semanticscholar   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris. [PDF]

Sci Rep
Lu Y, Zhang Y, Yao L, Yuan D, Yao B, Zhou B, He B.   +6 more
europepmc   +1 more source

Crystal structure, Hirshfeld surface analysis, calculations of crystal voids, interaction energy and energy frameworks as well as density functional theory (DFT) calculations of 3-[2-(morpholin-4-yl)ethyl]-5,5-diphenylimidazolidine-2,4-dione [PDF]

Houda Lamssane, Amal Haoudi, Badr Eddine Kartah, Ahmed Mazzah, Joel T. Mague, Tuncer Hökelek, Youssef Kandri Rodi, Nada Kheira Sebbar   +7 more
openalex   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

AbDrop-a scalable microfluidics-enabled platform for rapid discovery and functional analysis of plasma cell-derived antibodies. [PDF]

MAbs
Yu M, Wang L, Yang Y, Liang S, Ge Y, Xi H, Lin S, Chen Y, Liu W, Wang W, Zha C, Lu H.   +11 more
europepmc   +1 more source

STAMP: statistical analysis of taxonomic and functional profiles

Bioinform., 2014
Donovan H. Parks, G. Tyson, P. Hugenholtz, R. Beiko   +3 more
semanticscholar   +1 more source