Results 61 to 70 of about 3,444,674 (308)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

Scientific Reports
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli, Daniela Rodrigues, Kevin Portmann, Aline Linder, Marina Thoma, Cornelia Halin, Klaus Eyer   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Integrated chemical profiling of Camellia sinensis teas marketed in Brazil: Physicochemical, mineral, and volatile compound characterization

Food Chemistry Advances
Tea derived from Camellia sinensis is among the most widely consumed beverages worldwide, valued for its sensory diversity and health-promoting properties.
Natalie da Silva Aragão, Midori Nakamura Marques, Bruna Ribeiro de Lima, Ariane de Aguiar Queiros, Esther Belo de Souza, Raimundo Carlos Pereira Júnior, Wallice Paxiúba Duncan, Jaime Paiva Lopes Aguiar, Vanessa de Souza Marinho, Francisca das Chagas do Amaral Souza   +9 more
doaj   +1 more source

New Bisabosquals from Stachybotrys sp. PH30583 Elicited on Solid Media

Molecules, 2018
Stachybotrys sp. PH30583 cultured in liquid medium only led to one structure type of novel isochroman dimers. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Stachybotrys sp. PH30583 cultured in rice solid medium
Bao-Hui Ruan, Shu-Quan Li, Xue-Qiong Yang, Ya-Bin Yang, Ya-Mei Wu, Li-Jiao Shi, Hai-Yue Yin, Hao Zhou, Zhong-Tao Ding   +8 more
doaj   +1 more source

The XTH Gene Family in Schima superba: Genome-Wide Identification, Expression Profiles, and Functional Interaction Network Analysis

, 2022
Zhongyi Yang, Rui Zhang, Zhichun Zhou
openalex   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Putting hands to rest: efficient deep CNN-RNN architecture for chemical named entity recognition with no hand-crafted rules

Journal of Cheminformatics, 2018
Chemical named entity recognition (NER) is an active field of research in biomedical natural language processing. To facilitate the development of new and superior chemical NER systems, BioCreative released the CHEMDNER corpus, an extensive dataset of ...
Ilia Korvigo, Maxim Holmatov, Anatolii Zaikovskii, Mikhail Skoblov   +3 more
doaj   +1 more source