Results 181 to 190 of about 557,186 (345)

Evolution of Protein Functional Annotation: Text Mining Study [PDF]

, 2022
Ekaterina V. Ilgisonis, Pavel V. Pogodin, Olga I. Kiseleva, Svetlana Tarbeeva, Elena A. Ponomarenko   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium [PDF]

, 2011
Pascale Gaudet, Michael Livstone, Suzanna Lewis, Paul D. Thomas   +3 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

NapRNAdb: a multispecies repository and analytical platform for napRNA discovery and functional annotation. [PDF]

Nucleic Acids Res
Xuan J, Xiao C, Luo Y, Tang S, Pang J, Chen Z, Liu W, He QY.   +7 more
europepmc   +1 more source

Hayai-Annotation: A functional gene prediction tool that integrates orthologs and gene ontology for network analysis in plant species [PDF]

Andrea Ghelfi, Sachiko Isobe
openalex   +1 more source

In Vivo Functional Proteomics: Mammalian Genome Annotation Using CD-Tagging [PDF]

, 2002
Jonathan W. Jarvik, Gregory W. Fisher, C. Shi, L. Hennen, Christopher R. Hauser, Sally A. Adler, Peter B. Berget   +6 more
openalex   +1 more source

Editorial: Intelligent Systems for Genome Functional Annotations [PDF]

Frontiers in Genetics, 2020
Shandar Ahmad, Pedro J. Ballester, Pedro J. Ballester, Pedro J. Ballester, Pedro J. Ballester, Michael Fernandez   +5 more
openaire   +5 more sources