Results 201 to 210 of about 563,469 (347)

LLM-Assisted Functional Gene Annotation

Abstract Functional gene annotation is a highly manual and subjective process that requires analysis of large amounts of statistical and literature results. Here we present Artificial Intelligence Gene Enrichment (AIGE), a careful automation of the current state of the art process used by bioinformatic experts to deter-mine functions ...
Calvin Boyce, Clara Pereira, Gyeong Dae Kim, Allegra Petti   +3 more
openaire   +1 more source

Dormice functional genome annotation project: the first insights on regulation of hibernation

, 2022
H Carey, T Matthew, L Sandra, F Hoelzl, K Vermillion, K Anderson, M Hampton, M Andrews, K Storey   +8 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

NapRNAdb: a multispecies repository and analytical platform for napRNA discovery and functional annotation. [PDF]

Nucleic Acids Res
Xuan J, Xiao C, Luo Y, Tang S, Pang J, Chen Z, Liu W, He QY.   +7 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

FAVOR 2.0: A reengineered functional annotation of variants online resource for interpreting genomic variation. [PDF]

Nucleic Acids Res
Zhou H, Verma V, Li X, Li Z, Shedd N, Li TC, Yang H, Zhang A, Borsari B, Buyske S, Gerstein M, Matise T, Zody MC, Neale B, Weng Z, Sunyaev SR, Lin X.   +16 more
europepmc   +1 more source

Exploring protein sequences and functional annotations with UniProt

, 2023

openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization. [PDF]

Nucleic Acids Res
Feng X, Zheng J, Peng S, Jiang A, Ng KH, Lyu C, Jin Q, Chen L.   +7 more
europepmc   +1 more source

Functional annotation of predicted genes from Hiroshima-derived Magallana gigas

Imai, Misako
openalex   +1 more source