Results 191 to 200 of about 563,469 (347)

Integrative Functional Annotation of 52 Genetic Loci Influencing Myocardial Mass Identifies Candidate Regulatory Variants and Target Genes [PDF]

, 2019
Daiane Hemerich, Jiayi Pei, Magdaléna Harakaľová, Jessica van Setten, Sander Boymans, Bastiaan J. Boukens, Igor R. Efimov, Michelle Michels, Jolanda van der Velden, Aryan Vink, Caroline Cheng, Pim van der Harst, Jason H. Moore, Michal Mokrý, Vinicius Tragante, Folkert W. Asselbergs   +15 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Editorial: Intelligent Systems for Genome Functional Annotations [PDF]

Frontiers in Genetics, 2020
Shandar Ahmad, Pedro J. Ballester, Pedro J. Ballester, Pedro J. Ballester, Pedro J. Ballester, Michael Fernandez   +5 more
openaire   +5 more sources

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium [PDF]

, 2011
Pascale Gaudet, Michael Livstone, Suzanna Lewis, Paul D. Thomas   +3 more
openalex   +1 more source

Table S1. Primers used in the functional gene study;Table S2. Primers for dsRNA synthesis;Table S3. Summary of transcriptome sequencing and assembly for A. parthenogenetica;Table S4. The annotation results between unigenes and seven databases ;Table S5. The similar species and Genbank of VgR were compared by NCBI from Patio-temporal patterns of ovarian development and Very gene silencing reduced fecundity in parthenogenetic Artemia

, 2023
Hu Duan, Xuanxuan Shao, Wei Liu, Jianhai Xiang, Namin Pan, Xuehui Wang, Guoru Du, Ying Li, Jiaping Zhou, Liying Sui   +9 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Temporal dynamics and functional annotation of transcriptome rhythmicity in HEK293T cells. [PDF]

PLoS One
Sun Y, Dong H, Ge F, Zhao Y, Yang S, Ding Y, Dong M, Wang L, Zhang T.   +8 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A contamination-reduced genome of Plasmodiophora brassicae with comprehensive functional annotation. [PDF]

BMC Microbiol
Sedaghatkish A, Kunz M, Gossen BD, McDonald MR.   +3 more
europepmc   +1 more source