Results 191 to 200 of about 361,695 (297)

FAVOR 2.0: A reengineered functional annotation of variants online resource for interpreting genomic variation. [PDF]

Nucleic Acids Res
Zhou H, Verma V, Li X, Li Z, Shedd N, Li TC, Yang H, Zhang A, Borsari B, Buyske S, Gerstein M, Matise T, Zody MC, Neale B, Weng Z, Sunyaev SR, Lin X.   +16 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Metagenomic Tools for Taxonomic and Functional Annotation

, 2021
Yordanis Pérez-Llano, Ramon Alberto Batista-García, María del Rayo Sánchez-Carbente, Jorge Luis Folch-Mallol, Sara Cuadros-Orellana, Alma Delia Nicolás-Morales, Natividad Castro-Alarcón   +6 more
openaire   +3 more sources

CNAScope: pan-cancer copy number aberration database with functional annotation and interactive visualization. [PDF]

Nucleic Acids Res
Feng X, Zheng J, Peng S, Jiang A, Ng KH, Lyu C, Jin Q, Chen L.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Structural Characterization and Functional Annotation of Hypothetical Proteins in the Multidrug-Resistant Strains of <i>Pseudomonas aeruginosa</i>. [PDF]

Biomed Res Int
Khoonsari FN, Zafari Z.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

RNAStructuromeDB: a transcriptome-wide database of predicted RNA secondary structures with integrated APIs for functional annotation and RNA-targeted drug discovery. [PDF]

NAR Genom Bioinform
Dapour AO, Manigrasso J, Rouse WB, La Sala G, Aronnax MV, De Maria L, Hamilton RS, Cuesta SM, Hogner A, Moss WN.   +9 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Targeting Protein-Protein Interactions (PPIs) to Drive Functional Annotation: An Integrative Methodology to Study Senescence-Associated PPIs Using TMPRSS11a as Model Interactor. [PDF]

Biomolecules
Rosales-Rojas R, Fernández C, González-Avendaño M, Vergara-Jaque A, Cáceres M.   +4 more
europepmc   +1 more source