Results 181 to 190 of about 563,469 (347)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Functional annotation of the vlinc class of non-coding RNAs using systems biology approach

, 2016
Georges St. Laurent, Yuri V. Vyatkin, Денис Антонец, Maxim Ri, Qi Yao, Olga Saik, Dmitry Shtokalo, Michiel de Hoon, Hideya Kawaji, Masayoshi Itoh, Timo Lassmann, Peter Arner, Alistair R. R. Forrest, Estelle Nicolas, Timothy A. McCaffrey, Piero Carninci, Yoshihide Hayashizaki, Claes Wahlestedt, Philipp Kapranov   +18 more
openalex   +1 more source

A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data [PDF]

, 2015
Qiongshi Lu, Yiming Hu, Jiehuan Sun, Yu‐Wei Cheng, Kei‐Hoi Cheung, Hongyu Zhao   +5 more
openalex   +1 more source

Functional annotation of enzyme-encoding genes using deep learning with transformer layers

, 2023
Gi Bae Kim, Ji Yeon Kim, Jong An Lee, Charles J. Norsigian, Bernhard Ø. Palsson, Sang Yup Lee   +5 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA [PDF]

, 2015
Yinan Du, Qingzhou Meng, Jun Zhang, Man Sun, Bin Shen, Hui Jiang, Nannan Kang, Jimin Gao, Xingxu Huang, Jianghuai Liu   +9 more
openalex   +1 more source

Identification and Functional Annotation of Genes Related to Bone Stability in Laying Hens Using Random Forests [PDF]

, 2021
Simon Jansen, Ulrich Baulain, Christin Habig, Faisal Ramzan, Jens Schauer, Armin O. Schmitt, A. Scholz, Ahmad Sharifi, Annett Weigend, Steffen Weigend   +9 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Structural and Functional Analysis of Rv3214 from Mycobacterium tuberculosis , a Protein with Conflicting Functional Annotations, Leads to Its Characterization as a Phosphatase

, 2006
Harriet A. Watkins, Edward N. Baker
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source