Results 91 to 100 of about 4,689,287 (347)

Functional Pearl: The Distributive $$\lambda $$-Calculus [PDF]

, 2020
Beniamino Accattoli, Alejandro Díaz-Caro   +1 more
openalex   +1 more source

Towards a Neural Lambda Calculus: Neurosymbolic AI Applied to the Foundations of Functional Programming [PDF]

, 2023
João Flach, Luís C. Lamb, Lamb, Luis C.   +2 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Density problem some of the fractional functional spaces viaconformable fractional calculus and their application

, 2023
Fatima Zohra, Ladrani Amin, B. Chérif, Juan E. Nápoles Valdés, Fatima Ladrani, Benaissa Amin, Cherif, A Benaissa Cherif, F Ladrani, A Benaissa Cherif, F Ladrani, B Bendouma, A Benaissa Cherif, A Hammoudi, A Benaissa Cherif, F Ladrani, F Ladrani, A Benaissa Cherif, F Ladrani, A Benaissa Cherif, A Beniani, Kh Zennir, S Georgiev, N Benkhettou, S Hassani, D Torres, J Daz, T Osler, B Bayour, D Torres, Y Wang, J Zhou, Y Li, A Trajkovic, J Manojlovic, A Trajkovic, J Manojlovic, Khalil, Al Horani, Yousef, M Sababheh, J Npoles, P Guzmn, L Lugo, A Kashuri, P Guzmn, L Lugo, Npoles, J Valds, M Vivas-Cortez, K Owolabi, A Shikongo, A Atangana, A Akgl, K Owolabi, J He, S Djennadi, N Shawagfeh, O Abu Arqub   +58 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Functional calculus and quantization commutes with reduction for Toeplitz operators on CR manifolds [PDF]

, 2021
Andrea Galasso, Chin-Yu Hsiao
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Can female urethral calculus present with acute urinary retention?

Formosan Journal of Surgery, 2018
Urethral calculus is a very rare cause obstructive uropathy. Incidence of urethral calculus is extremely rare, less often in females as compared to males. It is usually associated with genitourinary pathology.
M Mahele, M S Faridi, Khumukchum Somarendra Singh, Rajendra Sinam Singh   +3 more
doaj   +1 more source