Results 111 to 120 of about 4,689,287 (347)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Functional calculus for noncommuting operators.
Michigan Mathematical Journal, 1995 Let \(F^2(H_n)={\mathbf C}1\oplus \bigoplus_{m\geq 1} H_n^{\otimes m}\) be the Fock space. \({\mathcal P}\) denotes the set of all \(p\in F^2(H_n)\) of the form: \(p=a_0+\sum a_{i_1\dots i_k} e_{i_1}\otimes\cdots\otimes e_{i_k}\), \(1\leq i_1,\dots, i_k\leq n\) and \(1\leq k\leq m\) where \(a_0,a_{i_1\dots i_k}\in{\mathbf C}\) and \(\{e_1,\dots, e_n\}\)
openaire +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The unbounded extension of Hille-Phillips functional calculus [PDF]
, 2019 А. Р. Миротин
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Borel functional calculus for quaternionic normal operators [PDF]
, 2017 G. Ramesh, P. Santhosh Kumar
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Functional calculus on Nœtherian schemes
Comptes Rendus. Mathématique, 2014 The present note is devoted to the functional calculus problem for sections of a quasi-coherent sheaf on a Nœtherian scheme. We prove scheme-theoretic analogs of the known results on the multivariable holomorphic functional calculus over Fréchet modules which are mainly due to of J. Taylor and M. Putinar. The generalization of the Taylor joint spectrum
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source