Results 31 to 40 of about 463 (229)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

NetWalker: a contextual network analysis tool for functional genomics [PDF]

BMC Genomics, 2012
Functional analyses of genomic data within the context of a priori biomolecular networks can give valuable mechanistic insights. However, such analyses are not a trivial task, owing to the complexity of biological networks and lack of computational methods for their effective integration with experimental data.We developed a software application suite,
Komurov Kakajan, Dursun Serkan, Erdin Serkan, Ram Prahlad T   +3 more
openaire   +3 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Optimise behavioural health and human factors research for deep space missions by classifying analogue scenarios and fidelity

Frontiers in Space Technologies
Future human space missions beyond low Earth orbit face significant challenges in understanding and managing astronaut behaviour and performance in extreme environments, with behavioural health remaining a critical knowledge gap.
Károly Kornél Schlosser, Károly Kornél Schlosser, Károly Kornél Schlosser, Károly Kornél Schlosser, Ilaria Cinelli, Ilaria Cinelli, Thorsten Waelde, Thorsten Waelde, Luis Luque Álvarez, Gábor Pokorádi, Krisztián Pósch, Iya Whiteley   +11 more
doaj   +1 more source

Brain Dynamical Networks: Contextualizing the Function of Primary Cortices [PDF]

Journal of Neuroscience, 2013
The rodent whisker system has been a productive model to study neocortical sensory function, featuring a variety of whisker-dependent behavioral tasks, experimental accessibility to neocortical electrophysiological measurements, and well characterized neuroanatomical circuitry.
Jonathan, Wimmer Del Solar, Daniel, Rojas-Líbano   +1 more
openaire   +2 more sources

Cognitive Status in People With Epilepsy in the Republic of Guinea: A Prospective, Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with epilepsy (PWE) may experience cognitive deficits but fail to undergo formal evaluation. This study compares cognitive status between PWE and healthy controls in the West African Republic of Guinea. Methods A cross‐sectional, case–control study was conducted in sequential recruitment phases (July 2024–July 2025) at Ignace ...
Maya L. Mastick, Cheick O. Soumah, Malé Doré, Oumar Mara, Desiré Neldje, Fodé A. Cissé, Toure M. Lamine, Aminata Diallo, Seungwon Lee, Siddharth Satish, Alexander J. X. Chen, Alice Liu, Nomin Enkhtsetseg, Farrah J. Mateen, The Guinea Epilepsy Project   +14 more
wiley   +1 more source

TRANSFER OF CONTEXTUAL STIMULUS FUNCTION VIA EQUIVALENCE CLASS DEVELOPMENT [PDF]

Journal of the Experimental Analysis of Behavior, 1989
In a conditional discrimination, 6 college students arranged six Cyrillic letters into groups of three based upon which of two additional Cyrillic letters (contextual stimuli) was present. All subjects demonstrated symmetry and transitivity within each class of equivalent stimuli.
M B, Gatch, J G, Osborne
openaire   +2 more sources

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source