Results 121 to 130 of about 3,633,355 (289)

Exploratory functional data analysis

TEST
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Zhuo Qu, Wenlin Dai, Carolina Euan, Ying Sun, Marc G. Genton   +4 more
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

THU0115 Psychological and functional states predict disease flare following tnf inhibitor tapering in patients with rheumatoid arthritis: a post-hoc analysis of data from the optimisingtnf tapering in ra (OPTTIRA) cohort [PDF]

, 2018
Katie Bechman, Fang En Sin, Fowzia Ibrahim, Sam Norton, D L Scott, Andrew P. Cope, James Galloway   +6 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

PhyloFunc: phylogeny-informed functional distance as a new ecological metric for metaproteomic data analysis [PDF]

Luman Wang, Caitlin M. A. Simopoulos, Joeselle M. Serrana, Zhibin Ning, Yutong Li, Boyan Sun, Jun Yuan, Daniel Figeys, Leyuan Li   +8 more
openalex   +3 more sources

A Study of the Colombian Stock Market with Multivariate Functional Data Analysis (FDA)

Mathematics
In this work, Functional Data Analysis (FDA) is used to detect behavioral patterns in the Bolsa de Valores de Colombia (BVC) in reaction to the global crises caused by COVID-19 and the war in Ukraine.
Deivis Rodríguez Cuadro, Sonia Pérez-Plaza, Antonia Castaño-Martínez, Fernando Fernández-Palacín   +3 more
doaj   +1 more source

A Statistical Framework to Predict Functional Non-Coding Regions in the Human Genome Through Integrated Analysis of Annotation Data [PDF]

, 2015
Qiongshi Lu, Yiming Hu, Jiehuan Sun, Yu‐Wei Cheng, Kei‐Hoi Cheung, Hongyu Zhao   +5 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Generalized Partially Functional Linear Model with Interaction between Functional Predictors

Axioms
This paper proposes a generalized partially functional linear model with interaction terms. It is suitable for cases where the response variable is scalar, and the predictor variables include a mix of functional and scalar types, while considering the ...
Weiwei Xiao, Kejing Mao, Haiyan Liu
doaj   +1 more source