Results 181 to 190 of about 3,633,355 (289)

Data from Ethnic Differences and Functional Analysis of MET Mutations in Lung Cancer

, 2023
Soundararajan Krishnaswamy, Rajani Kanteti, Jonathan S. Duke‐Cohan, Sivakumar Loganathan, Wanqing Liu, Caswell Patrick, Martin Sattler, Patrick A. Singleton, Nithya Ramnath, Federico Innocenti, Dan L. Nicolae, Zheng Ouyang, Jie Liang, John D. Minna, Mark Kozloff, Mark K. Ferguson, Viswanathan Natarajan, Yi‐Ching Wang, Joe G. N. Garcia, Everett E. Vokes, Ravi Salgia   +20 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Scalar-on-Shape Regression Models for Functional Data Analysis [PDF]

Sayan Bhadra, Anuj Srivastava
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Identifying predictors of formal help-seeking for premenstrual symptoms: A machine learning analysis of symptom, functional impairment and barriers data

Erin L. Funnell, Nayra A Martin-Key, Jakub Tomasik, Sabine Bahn   +3 more
openalex   +2 more sources

Functional annotation and pathway analysis of genes differentially expressed in different stages of Plasmodium falciparum using RNA-Seq Data

, 2017
Sanjay K. Singh, Adeel Malik, Ahmad Firoz, Khushboo Gupta, M. Sudhakara Reddy   +4 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Methods and Applications of Multivariate Pattern Analysis in Functional MRI Data Analysis.

, 2015
Yash Shah
openalex   +1 more source

Functional data analysis of prosodic prominence in Parkinson’s disease: a pilot study

, 2023
Lauri Tavi, Nelly Penttilä
openalex   +1 more source