Results 171 to 180 of about 6,800,650 (283)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Functional data analysis of ground reaction forces combined with clinical measures for early knee osteoarthritis detection. [PDF]

Sci Rep
Aragón-Basanta E, Page A, Ayala G, Viosca-Herrero E, Alabajos-Cea A, Herrero-Manley L.   +5 more
europepmc   +1 more source

Separation of Chromatographic Co-Eluted Compounds by Clustering and by Functional Data Analysis. [PDF]

Metabolites, 2021
Sawikowska A, Piasecka A, Kachlicki P, Krajewski P.   +3 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Functional Data Analysis for the Structural, Chemical, Thermal, and Mechanical Properties of PA12 Additively Manufactured via SLS. [PDF]

Polymers (Basel)
García Rodríguez A, Reyes YG, Espejo Mora E, Narváez Tovar CA, Velasco Peña MA.   +4 more
europepmc   +1 more source

The investigation of temperature data in Turkey's Black Sea Region using functional data analysis. [PDF]

J Appl Stat, 2022
Sözen Ç, Öner Y.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Functional data analysis of heart rate variability from continuous ECG monitoring in older adults with and without mild cognitive impairment. [PDF]

Front Aging Neurosci
Qin J, Derby CA, Liu G, Wang C, Sloan RP.   +4 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Longitudinal trajectories of insulin resistance in women with polycystic ovary syndrome: a functional data analysis approach. [PDF]

Endocr Connect
Ramezani Tehrani F, Fayaz M, Firouzi F, Azizi F, Tohidi M, Behboudi-Gandevani S.   +5 more
europepmc   +1 more source