Results 151 to 160 of about 3,338,515 (259)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Functional data analysis of ground reaction forces combined with clinical measures for early knee osteoarthritis detection. [PDF]

Sci Rep
Aragón-Basanta E, Page A, Ayala G, Viosca-Herrero E, Alabajos-Cea A, Herrero-Manley L.   +5 more
europepmc   +1 more source

From multivariate to functional data analysis: fundamentals, recent developments, and emerging areas. [PDF]

J Multivar Anal, 2022
Li Y, Qiu Y, Xu Y.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Contribution of Longitudinal Mobile Health Measures in the Dynamic Track of Patients With Major Depressive Disorder: Multiple Centers, Prospective Cohort Study Using Functional Data Analysis and Machine Learning. [PDF]

JMIR Mhealth Uhealth
Zhong R, Li N, Xiao L, Feng L, Feng Y, Wang G, Zhu X.   +6 more
europepmc   +1 more source

Revisit to functional data analysis of sleeping energy expenditure. [PDF]

J Appl Stat, 2022
Baek S, Kim Y, Park J, Lee JS.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Functional Data Analysis for the Structural, Chemical, Thermal, and Mechanical Properties of PA12 Additively Manufactured via SLS. [PDF]

Polymers (Basel)
García Rodríguez A, Reyes YG, Espejo Mora E, Narváez Tovar CA, Velasco Peña MA.   +4 more
europepmc   +1 more source

Separation of Chromatographic Co-Eluted Compounds by Clustering and by Functional Data Analysis. [PDF]

Metabolites, 2021
Sawikowska A, Piasecka A, Kachlicki P, Krajewski P.   +3 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source