Results 61 to 70 of about 3,232,072 (306)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Enhancing PQQ production in Acinetobacter calcoaceticus through uniform design and support vector regression

Frontiers in Microbiology
A novel machine learning-assisted approach for formula optimization, termed UD-SVR, is introduced by combining uniform design with support vector regression.
Yu-han Li, Yu-han Li, Su-hang Yao, Su-hang Yao, Yan Zhou, Xiu-lan He, Xiu-lan He, Zhe-ming Yuan, Zhe-ming Yuan, Qiu-long Hu, Cheng-wen Shen, Xin Li, Xin Li, Yuan Chen   +13 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A tool for generation of stochastic occupant-based internal loads using a functional data analysis approach to re-define ‘activity’ [PDF]

, 2021
Rebecca Ward, Ruchi Choudhary
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Editorial: Advances in thrombin generation

Frontiers in Cardiovascular Medicine, 2023
Romy de Laat-Kremers, Stéphane Zuily, Bas de Laat, Bas de Laat   +3 more
doaj   +1 more source

Advanced Statistical Analysis of 3D Kinect Data: Mimetic Muscle Rehabilitation Following Head and Neck Surgeries Causing Facial Paresis

Sensors, 2020
An advanced statistical analysis of patients’ faces after specific surgical procedures that temporarily negatively affect the patient’s mimetic muscles is presented.
Jan Kohout, Ludmila Verešpejová, Pavel Kříž, Lenka Červená, Karel Štícha, Jan Crha, Kateřina Trnková, Martin Chovanec, Jan Mareš   +8 more
doaj   +1 more source

Estimating Sleep & Work Hours from Alternative Data by Segmented Functional Classification Analysis (SFCA) [PDF]

, 2020
Klaus Ackermann, Simon D. Angus, Paul A. Raschky   +2 more
openalex   +1 more source

Improved Discontinuous Lyapunov Functionals for Stability Analysis of Sampled-Data Systems [PDF]

, 2021
Binh Nguyen, Sung Hyun Kim
openalex   +1 more source