Results 61 to 70 of about 57,558 (262)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Multivariate information theory uncovers synergistic subsystems of the human cerebral cortex

open access: yesCommunications Biology, 2023
One of the most well-established tools for modeling the brain is the functional connectivity network, which is constructed from pairs of interacting brain regions.
Thomas F. Varley   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Methodical bases of functioning of the system model information and telemetric ensuring starts of rockets of space appointment

open access: yesФизика волновых процессов и радиотехнические системы, 2018
Defines the basic structural-elements of functioning of a system of information telemetry ensuring starts rockets of space appointment. The contents of information processes in the system of information telemetry ensuring starts rockets of space ...
A.V. Kuimov, A.V. Kononenko
doaj  

A malware detection method with function parameters encoding and function dependency modeling [PDF]

open access: yesPeerJ Computer Science
As computers are widely used in people’s work and daily lives, malware has become an increasing threat to network security. Although researchers have introduced traditional machine learning and deep learning methods to conduct extensive research on ...
Ronghao Hou   +4 more
doaj   +2 more sources

Multi-genome metabolic modeling predicts functional inter-dependencies in the Arabidopsis root microbiome

open access: yesMicrobiome, 2022
Background From a theoretical ecology point of view, microbiomes are far more complex than expected. Besides competition and competitive exclusion, cooperative microbe-microbe interactions have to be carefully considered.
Alice Mataigne   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On the Family of Conditional Embedded Implicational Dependencies [PDF]

open access: yesComputer Science Journal of Moldova, 1996
Certain second-order sentences, called conditional embedded implicational dependencies, about relations in a relational database, are defined and studied. This class of dependencies includes some of previously defined dependencies as special cases. Thus,
Victor Felea
doaj  

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