Results 81 to 90 of about 3,507,101 (291)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Bernstein Algorithm for Vertical Normalization to 3NF Using Synthesis
Ekonomski Vjesnik, 2013 This paper demonstrates the use of Bernstein algorithm for vertical normalization to 3NF using synthesis. The aim of the paper is to provide an algorithm for database normalization and present a set of steps which minimize redundancy in order to increase
Matija Varga
doaj
Behavioral SciencesPrompt dependency is a common concern for individuals with developmental disabilities, particularly autism spectrum disorder. Previous research has shown that different interventions can be used to decrease prompt dependency.
Jennifer R. Weyman +2 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
BMJ Mental HealthBackground With rapid population ageing, depressive symptoms in older adults have become a pressing public health concern. While functional dependency is a known risk factor, the impact of changes in dependency over time remains unclear.Objective To ...
Hongwei Liu +4 more
doaj +1 more source
A Uniform Dependency Language for Improving Data Quality [PDF]
, 2011 A variety of dependency formalisms have been studied for improving data quality. To treat these dependencies in a uniform framework, we propose a simple language, Quality Improving Dependencies (QIDs).
Fan, Wenfei; id_orcid, Geerts, Floris
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Irish treebanking and parsing: a preliminary evaluation [PDF]
, 2012 Language resources are essential for linguistic research and the development of NLP applications. Low- density languages, such as Irish, therefore lack significant research in this area.
Lynn, Teresa +5 more
core +2 more sources
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source