Results 91 to 100 of about 171,909 (299)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

An open source rule induction tool for transfer-based SMT [PDF]

open access: yes, 2009
In this paper we describe an open source tool for automatic induction of transfer rules. Transfer rule induction is carried out on pairs of dependency structures and their node alignment to produce all rules consistent with the node alignment.
Graham, Yvette, van Genabith, Josef
core  

Conceptual-based Functional Dependency Detection Framework [PDF]

open access: yes, 2016
Nowadays, knowledge discovery from data is one of the challenging problems, due to its importance in different fields such as; biology, economy and social sciences.
Islam, Fahad, Fahad Islam
core   +1 more source

Bernstein Algorithm for Vertical Normalization to 3NF Using Synthesis

open access: yesEkonomski Vjesnik, 2013
This paper demonstrates the use of Bernstein algorithm for vertical normalization to 3NF using synthesis. The aim of the paper is to provide an algorithm for database normalization and present a set of steps which minimize redundancy in order to increase
Matija Varga
doaj  

Changes in daily living dependency and incident depressive symptoms among older individuals: findings from four prospective cohort studies

open access: yesBMJ Mental Health
Background With rapid population ageing, depressive symptoms in older adults have become a pressing public health concern. While functional dependency is a known risk factor, the impact of changes in dependency over time remains unclear.Objective To ...
Hongwei Liu   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Functional Dependency and Degeneracy: Detailed Analysis of the GAuGE System [PDF]

open access: yes, 2016
6th International Conference, Evolution Artificielle, EA 2003, Marseille, France, 27-30 October 2003This paper explores the mapping process of the GAuGE system, a recently introduced position-independent genetic algorithm, that encodes both the positions
Ryan, Conor   +2 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Automatic treebank-based acquisition of Arabic LFG dependency structures [PDF]

open access: yes, 2009
A number of papers have reported on methods for the automatic acquisition of large-scale, probabilistic LFG-based grammatical resources from treebanks for English (Cahill and al., 2002), (Cahill and al., 2004), German (Cahill and al., 2003), Chinese ...
Attia, Mohammed   +2 more
core  

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