Results 31 to 40 of about 120,037 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Functional differential equations close to differential equations [PDF]

open access: yesBulletin of the American Mathematical Society, 1966
when the lag function r(t) is nearly constant for large /, and has also asked for conditions on the function r under which all solutions approach zero as t—» oo. The purpose of this announcement is to initiate a study of various stability and oscillation problems for equations with perturbed lag functions, and to suggest that a modification of the ...
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The eigenvalue product bounds of the Lyapunov matrix differential equation and the stability of a class of time-varying nonlinear system

open access: yesJournal of Inequalities and Applications, 2019
The Lyapunov matrix differential equation plays an important role in many scientific and engineering fields. In this paper, we first give a class relation between the eigenvalue of functional matrix derivative and the derivative of functional matrix ...
Jianzhou Liu, Juan Zhang, Hao Huang
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hyers-Ulam-Rassias Stability for a First Order Functional Differential Equation

open access: yesJournal of Mathematical and Fundamental Sciences, 2015
In this paper, by using the fixed point method, we prove two new results on the Hyers-Ulam-Rassias and the Hyers-Ulam stability for the first order delay differential equation of the form y′(t) = F(t, y(t), y(t −τ )).
Cemil Tunç, Emel Biçer
doaj   +1 more source

Oscillation of certain functional differential equations [PDF]

open access: yesComputers & Mathematics with Applications, 1994
The author presents several sufficient conditions for all bounded solutions to the linear system of delay differential equations \[ (-1)^{m+1}\frac {d^m y_i(t)}{d t^m}+\sum _{j=1}^{n}q_{ij}y_i(t-h_{ij})=0, \quad m\geq 1,\;i=1,2,\dots,n, \] to be oscillatory.
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Analytic solution of certain second-order functional differential equation

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2006
We consider the existence of analytic solutions of a certain class of iterative second-order functional differential equation of the form x″(x[r](z))=c0z2+c1(x(z))2+(c2x[2](z))2+⋯+cm(x[m](z))2, m,r≥0.
Theeradach Kaewong, Piyapong Niamsup
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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